A qualitative study on the experiences of autologous haematopoietic stem cell transplant for Multiple Sclerosis

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dc.check.date2025-11-15en
dc.check.infoAccess to this article is restricted until 12 months after publication by request of the publisheren
dc.contributor.authorDavenport, Lauraen
dc.contributor.authorMcCauley, Mathewen
dc.contributor.authorSmyth, Liamen
dc.contributor.authorReynolds, Audreyen
dc.contributor.authorGaughan, Mariaen
dc.contributor.authorTubridy, Niallen
dc.contributor.authorMcGuigan, Chrisen
dc.contributor.authorO'Keeffe, Fiadhnaiten
dc.date.accessioned2024-12-10T11:28:35Z
dc.date.available2024-12-10T11:28:35Z
dc.date.issued2024-11-15en
dc.description.abstractAim: Autologous haematopoietic stem cell transplant (HSCT) is an effective treatment for people with highly-active relapsing multiple sclerosis (MS), who are not adequately responding to disease-modifying therapies. To date, research has predominantly focused on disease-specific outcome measures. There is a lack of research exploring patient experiences of this complex treatment. The study aims to explore the experience of considering and receiving HSCT treatment for MS. Methods: Semi-structured interviews were conducted online with 12 adults with MS who had undergone HSCT treatment. Interview topics covered the experience of deciding on the treatment, the HSCT process itself, and the patient-reported outcomes following HSCT. Interviews were audio-recorded and transcribed verbatim. A thematic analysis approach was employed. Results: Three main themes were identified: (1) Balancing hope and fear explores the decision-making experience when considering HSCT as a treatment; (2) Distinct emotional experience, highlights the unique challenges faced on all stages of the treatment journey; and (3) Adjusting to outcomes, explores how participants make sense of the aftermath of the treatment, including managing the ongoing uncertainty of MS and complications arising from HSCT. Discussion: HSCT is a complex treatment, both physically and psychologically for pwMS. A comprehensive and holistic care pathway is required to support people with MS at all stages of the treatment process, to ensure patient-centred planning and care.en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid106165en
dc.identifier.citationDavenport, L., McCauley, M., Smyth, L., Reynolds, A., Gaughan, M., Tubridy, N. and McGuigan, C. (2024) 'A qualitative study on the experiences of autologous haematopoietic stem cell transplant for Multiple Sclerosis', Multiple Sclerosis and Related Disorders, 92, 106165 (8pp). https://doi.org/10.1016/j.msard.2024.106165en
dc.identifier.doihttps://doi.org/10.1016/j.msard.2024.106165en
dc.identifier.endpage8en
dc.identifier.issn2211-0348en
dc.identifier.journaltitleMultiple Sclerosis and Related Disordersen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/16718
dc.identifier.volume92en
dc.language.isoenen
dc.publisherElsevier B.V.en
dc.relation.ispartofMultiple Sclerosis and Related Disordersen
dc.rights© 2024, Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies. This manuscript version is made available under the CC BY-NC-ND 4.0 license.en
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectMultiple sclerosisen
dc.subjectHaematopoietic stem cell transplanten
dc.subjectQualitativeen
dc.subjectNeuropsychological outcomesen
dc.subjectPatient experienceen
dc.titleA qualitative study on the experiences of autologous haematopoietic stem cell transplant for Multiple Sclerosisen
dc.typeArticle (peer-reviewed)en
oaire.citation.volume92en
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