Neuromedin U mediates left atrial pressure–induced diuresis in the anaesthetised pig

Simple item page
dc.contributor.authorHealy, Vincent
dc.contributor.authorRuane O’Hora, Therese
dc.contributor.authorLucking, Eric
dc.contributor.authorO’Donoghue, Gerard
dc.contributor.authorMarkos, Farouk Hazim
dc.date.accessioned2026-05-22T14:50:06Z
dc.date.available2026-05-22T14:50:06Z
dc.date.issued2026-05-08
dc.description.abstractFinding a potential biomarker for elevated left atrial pressure would be clinically useful as a diagnostic for pre-heart failure. Therefore, an investigation into whether the protein neuromedin U (NMU), which is significantly elevated in heart failure patients, mediates a classical diuresis that results from a sustained increase in left atrial pressure was conducted in the anaesthetized pig. Left atrial pressure was increased a little above 15 mmHg for 30 minutes in 8 chloralose anaesthetised female pigs. There was a significant increase in circulating NMU and urine flow rate, which surprisingly occurred without an accompanying natriuresis; both the serum NMU increase and the diuresis did not occur when the procedure was repeated post-vagal section. There was also a significant increase in glomerular filtration rate during the diuresis, which indicates a likely direct renal effect. The results show that NMU could be the mediator of the historic diuresis induced by an increased left atrial pressure. Future work to assess NMU levels in humans in pre-heart failure would be required to confirm NMU’s potential usefulness as a diagnostic. © 2026 Healy et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en
dc.description.versionPublished Version
dc.format.extent8
dc.format.mimetypeapplication/pdfen
dc.identifier.articleide0348773
dc.identifier.authororcidHealy, Vincent
dc.identifier.authororcidRuane O’Hora, Therese
dc.identifier.authororcidLucking, Eric
dc.identifier.authororcidO’Donoghue, Gerard
dc.identifier.authororcidMarkos, Farouk Hazim
dc.identifier.citationHealy, V, Ruane O’Hora, T, Lucking, E, O’Donoghue, G & Markos, F H 2026, 'Neuromedin U mediates left atrial pressure–induced diuresis in the anaesthetised pig', Plos One., vol. 21, no. 5 , e0348773, pp. 1-8. https://doi.org/10.1371/journal.pone.0348773
dc.identifier.doi10.1371/journal.pone.0348773
dc.identifier.endpage8
dc.identifier.issn1932-6203
dc.identifier.issued5
dc.identifier.journaltitlePlos One.
dc.identifier.otherRIS: urn:95E4A7BBE9B52C7DB66B749138B5521F
dc.identifier.startpage1
dc.identifier.urihttps://hdl.handle.net/10468/18845
dc.identifier.volume21
dc.language.isoen
dc.publisherPublic Library of Science
dc.relation.urihttps://www.scopus.com/pages/publications/105038201302
dc.relation.urihttps://www.scopus.com/pages/publications/105038201302?origin=resultslist
dc.rights© 2026 Healy et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
dc.rights.accessrightsopen access
dc.rights.licensenameAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.statusPeer reviewed
dc.subjectNeuromedin U
dc.subjectPig
dc.subject[Medicine]
dc.titleNeuromedin U mediates left atrial pressure–induced diuresis in the anaesthetised pigen
dc.typeArticle (peer-reviewed)
Files
Original bundle
Now showing 1 - 2 of 2
Thumbnail Image
Name:
journal.pone.0348773.pdf
Size:
916.73 KB
Format:
Adobe Portable Document Format
Download
Thumbnail Image
Name:
journal.pone.0348773.s001.xlsx
Size:
18.7 KB
Format:
Microsoft Excel XML
Download
Collections
School of Medicine