Effect of an egg ovalbumin-derived protein hydrolysate on blood pressure and cardiovascular risk in adults with a mildly elevated blood pressure: a randomized placebo-controlled crossover trial

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dc.check.date2019-10-03
dc.check.infoAccess to this article is restricted until 12 months after publication by request of the publisher.en
dc.contributor.authorLucey, Alice J.
dc.contributor.authorHeneghan, Clara
dc.contributor.authorManning, Edmund
dc.contributor.authorKroon, Paul A.
dc.contributor.authorKiely, Mairead E.
dc.contributor.funderSeventh Framework Programmeen
dc.contributor.funderBiotechnology and Biological Sciences Research Councilen
dc.date.accessioned2018-10-08T13:41:23Z
dc.date.available2018-10-08T13:41:23Z
dc.date.issued2018-10-03
dc.date.updated2018-10-08T13:31:16Z
dc.description.abstractPurpose: While animal and in vitro data demonstrate vasodilatory effects of egg white-derived peptides, human studies are lacking. We investigated for the first time the effects of an egg ovalbumin-derived protein hydrolysate on blood pressure (BP) and cardiovascular risk. Methods: A double-blind, placebo-controlled randomized crossover trial was implemented in 75 adults aged 50–70 years with systolic BP (130–≤ 150 mmHg). Participants were randomized to an egg ovalbumin-derived protein hydrolysate (3 g/day) or placebo (3 g/day). Participants completed two 6-week periods separated by a 3-week washout. Results: Data from 65 participants with a mean systolic BP (135.1 ± 11 mmHg) were included. Mean office and central BP and arterial stiffness (assessed by carotid-femoral pulse wave velocity (cfPWV) or pulse wave analysis (PWA)) did not change over time and no significant differences were observed between the egg protein hydrolysate and placebo groups (P > 0.05). Similarly, no significant effects of this egg ovalbumin-derived protein hydrolysate on blood lipid and glucose concentrations (P > 0.05) were observed. Conclusion: This is the first dietary intervention to investigate the effects of egg ovalbumin-derived protein hydrolysates on cardiovascular risk in humans. Despite promising findings from animal and in vitro studies, this RCT does not support the hypothesis that consumption of an egg ovalbumin-derived protein hydrolysate for 6 weeks in adults with a high-normal BP results in a reduction in BP or the modification of cardiovascular risk.en
dc.description.sponsorshipBiotechnology and Biological Sciences Research Council (Food and Health Institute Strategic Programme Grant, BB/J004545/1)en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationLucey, A. J., Heneghan, C., Manning, E., Kroon, P. A. and Kiely, M. E. (2018) 'Effect of an egg ovalbumin-derived protein hydrolysate on blood pressure and cardiovascular risk in adults with a mildly elevated blood pressure: a randomized placebo-controlled crossover trial', European Journal of Nutrition, In Press, doi: 10.1007/s00394-018-1832-9en
dc.identifier.doi10.1007/s00394-018-1832-9
dc.identifier.endpage11en
dc.identifier.issn1436-6215
dc.identifier.journaltitleEuropean Journal of Nutritionen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/6992
dc.language.isoenen
dc.publisherSpringer Berlin Heidelbergen
dc.relation.projectinfo:eu-repo/grantAgreement/EC/FP7::SP1::KBBE/312090/EU/Beneficial effects of dietary bioactive peptides and polyphenols on cardiovascular health in humans/BACCHUSen
dc.relation.urihttps://doi.org/10.1007/s00394-018-1832-9
dc.rights© Springer-Verlag GmbH Germany, part of Springer Nature 2018. This is a post-peer-review, pre-copyedit version of an article published in European Journal of Nutrition. The final authenticated version is available online at: http://dx.doi.org/10.1007/s00394-018-1832-9en
dc.subjectBioactive peptidesen
dc.subjectBlood pressureen
dc.subjectCardiovascular risken
dc.subjectEgg whiteen
dc.subjectOvalbuminen
dc.titleEffect of an egg ovalbumin-derived protein hydrolysate on blood pressure and cardiovascular risk in adults with a mildly elevated blood pressure: a randomized placebo-controlled crossover trialen
dc.typeArticle (peer-reviewed)en
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