Phenobarbital reduces EEG amplitude and propagation of neonatal seizures but does not alter performance of automated seizure detection

dc.contributor.authorMathieson, Sean R.
dc.contributor.authorLivingstone, Vicki
dc.contributor.authorLow, Evonne
dc.contributor.authorPressler, Ronit
dc.contributor.authorRennie, Janet M.
dc.contributor.authorBoylan, Geraldine B.
dc.contributor.funderWellcome Trusten
dc.contributor.funderScience Foundation Irelanden
dc.date.accessioned2016-10-24T11:31:17Z
dc.date.available2016-10-24T11:31:17Z
dc.date.issued2016-07-25
dc.description.abstractObjective: Phenobarbital increases electroclinical uncoupling and our preliminary observations suggest it may also affect electrographic seizure morphology. This may alter the performance of a novel seizure detection algorithm (SDA) developed by our group. The objectives of this study were to compare the morphology of seizures before and after phenobarbital administration in neonates and to determine the effect of any changes on automated seizure detection rates. Methods: The EEGs of 18 term neonates with seizures both pre- and post-phenobarbital (524 seizures) administration were studied. Ten features of seizures were manually quantified and summary measures for each neonate were statistically compared between pre- and post-phenobarbital seizures. SDA seizure detection rates were also compared. Results: Post-phenobarbital seizures showed significantly lower amplitude (p < 0.001) and involved fewer EEG channels at the peak of seizure (p < 0.05). No other features or SDA detection rates showed a statistical difference. Conclusion: These findings show that phenobarbital reduces both the amplitude and propagation of seizures which may help to explain electroclinical uncoupling of seizures. The seizure detection rate of the algorithm was unaffected by these changes. Significance: The results suggest that users should not need to adjust the SDA sensitivity threshold after phenobarbital administration.en
dc.description.sponsorshipWellcome Trust (Strategic Translational Award (098983)); Science Foundation Ireland (SFI Principal Investigator (10/IN.1/B3036) and Research Centre Awards (12/RC/2272)en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationMathieson, S. R., Livingstone, V., Low, E., Pressler, R., Rennie, J. M. and Boylan, G. B. (2016) ‘Phenobarbital reduces EEG amplitude and propagation of neonatal seizures but does not alter performance of automated seizure detection,’ Clinical Neurophysiology, 127(10), pp. 3343-3350. doi: 10.1016/j.clinph.2016.07.007en
dc.identifier.doi10.1016/j.clinph.2016.07.007
dc.identifier.endpage3350en
dc.identifier.issn1388-2457
dc.identifier.issn1872-8952
dc.identifier.issued10en
dc.identifier.journaltitleClinical Neurophysiologyen
dc.identifier.startpage3343en
dc.identifier.urihttps://hdl.handle.net/10468/3210
dc.identifier.volume127en
dc.language.isoenen
dc.publisherElsevieren
dc.rights© 2016 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectAutomated seizure detectionen
dc.subjectElectroclinical uncouplingen
dc.subjectNeonatal seizuresen
dc.titlePhenobarbital reduces EEG amplitude and propagation of neonatal seizures but does not alter performance of automated seizure detectionen
dc.typeArticle (peer-reviewed)en
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