Biocidal inactivation of Lactococcus lactis bacteriophages: efficacy and targets of commonly used sanitizers

dc.contributor.authorHayes, Stephen
dc.contributor.authorMurphy, James
dc.contributor.authorMahony, Jennifer
dc.contributor.authorLugli, Gabriele A.
dc.contributor.authorVentura, Marco
dc.contributor.authorNoben, Jean-Paul
dc.contributor.authorFranz, Charles M. A. P.
dc.contributor.authorNeve, Horst
dc.contributor.authorNauta, Arjen
dc.contributor.authorvan Sinderen, Douwe
dc.contributor.funderScience Foundation Irelanden
dc.contributor.funderIrish Research Councilen
dc.contributor.funderUniversiteit Antwerpenen
dc.date.accessioned2017-03-03T10:02:40Z
dc.date.available2017-03-03T10:02:40Z
dc.date.issued2017-02-02
dc.date.updated2017-03-03T09:42:34Z
dc.description.abstractLactococcus lactis strains, being intensely used in the dairy industry, are particularly vulnerable to members of the so-called 936 group of phages. Sanitization and disinfection using purpose-made biocidal solutions is a critical step in controlling phage contamination in such dairy processing plants. The susceptibility of 36 936 group phages to biocidal treatments was examined using 14 biocides and commercially available sanitizers. The targets of a number of these biocides were investigated by means of electron microscopic and proteomic analyses. The results from this study highlight significant variations in phage resistance to biocides among 936 phages. Furthermore, rather than possessing resistance to specific biocides or biocide types, biocide-resistant phages tend to possess a broad tolerance to multiple classes of antimicrobial compounds.en
dc.description.sponsorshipScience Foundation Ireland (SFI Investigator Award Ref. No. 13/IA/1953; ); Irish Research Council (Enterprise Partnership Scheme Postgraduate Scholarship; Technology Innovation Development Award Ref. No. 14/TIDA/2287; Starting Investigator Research Grant Ref. No. 15/SIRG/3430); Universiteit Antwerpen (Hercules Foundation Project R-3986: LC–MS@UHasselt: Linear Trap Quadrupool-Orbitrap mass spectrometer.)en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid107
dc.identifier.citationHayes, S., Murphy, J., Mahony, J., Lugli, G. A., Ventura, M., Noben, J.-P., Franz, C. M. A. P., Neve, H., Nauta, A. and van Sinderen, D. (2017) ‘Biocidal inactivation of Lactococcus lactis bacteriophages: efficacy and targets of commonly used sanitizers’, Frontiers in Microbiology, 8, 107 ((14 pp). doi: 10.3389/fmicb.2017.00107en
dc.identifier.doi10.3389/fmicb.2017.00107
dc.identifier.endpage14en
dc.identifier.issn1664-302X
dc.identifier.journaltitleFrontiers In Microbiologyen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/3736
dc.identifier.volume8en
dc.language.isoenen
dc.publisherFrontiers Mediaen
dc.relation.urihttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC5288689/
dc.rights© 2017, the Authors. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectPhageen
dc.subjectFermentationen
dc.subjectStarter cultureen
dc.subjectDairyen
dc.subjectResistanceen
dc.subjectChemicalen
dc.titleBiocidal inactivation of Lactococcus lactis bacteriophages: efficacy and targets of commonly used sanitizersen
dc.typeArticle (peer-reviewed)en
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