Diffuse reflectance spectroscopy for determination of optical properties and chromophore concentrations of mice internal organs in the range of 350 nm to 1860 nm

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dc.contributor.authorNogueira, Marcelo Saito
dc.contributor.authorRaju, Michael
dc.contributor.authorGunther, Jacqueline
dc.contributor.authorGrygoryev, Konstantin
dc.contributor.authorKomolibus, Katarzyna
dc.contributor.authorLu, Huihui
dc.contributor.authorAndersson-Engels, Stefan
dc.contributor.editorPopp, Jürgen
dc.contributor.editorTuchin, Valery V.
dc.contributor.editorPavone, Francesco Saverio
dc.date.accessioned2021-09-21T11:54:53Z
dc.date.available2021-09-21T11:54:53Z
dc.date.issued2018-05-17
dc.date.updated2021-09-21T11:25:37Z
dc.description.abstractThe development of photomedical modalities for diagnostics and treatment has created a need for knowledge of the optical properties of the targeted biological tissues. These properties are essential to plan certain procedures, since they determine the light absorption, propagation and penetration in tissues. One way to measure these properties is based on diffuse reflectance spectroscopy (DRS). DRS can provide light absorption and scattering coefficients for each wavelength through a non-invasive, fast and in situ interrogation, and thereby tissue biochemical information. In this study, reflectance measurements of ex vivo mice organs were investigated in a wavelength range between 350 and 1860 nm. To the best of our knowledge, this range is broader than previous studies reported in the literature and is useful to study additional chromophores with absorption in the extended wavelength range. Also, it may provide a more accurate concentration of tissue chromophores when fitting the reflectance spectrum in this extended range. In order to extract these concentrations, optical properties were calculated in a wide spectral range through a fitting routine based on an inverse Monte-Carlo look-up table model. Measurements variability was assessed by calculating the Pearson correlation coefficients between each pair of measured spectra of the same type of organ.en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid106853Gen
dc.identifier.citationNogueira, M. S., Raju, M., Gunther, J., Grygoryev, K., Komolibus, K., Lu, H. and Andersson-Engels, S. (2018) 'Diffuse reflectance spectroscopy for determination of optical properties and chromophore concentrations of mice internal organs in the range of 350 nm to 1860 nm', SPIE Photonics Europe 2018, Strasbourg, France, 23-26 April. Proceedings Volume 10685, Biophotonics: Photonic Solutions for Better Health Care VI; 106853G (2018). doi: 10.1117/12.2306636en
dc.identifier.doi10.1117/12.2306636en
dc.identifier.eissn1996-756X
dc.identifier.issn0277-786X
dc.identifier.journaltitleProceedings of SPIEen
dc.identifier.urihttps://hdl.handle.net/10468/11972
dc.identifier.volume10685en
dc.language.isoenen
dc.publisherSociety of Photo-Optical Instrumentation Engineers (SPIE)en
dc.relation.ispartofSPIE Photonics Europe 2018, Strasbourg, France, 22-26 April
dc.relation.ispartofProceedings Volume 10685, Biophotonics: Photonic Solutions for Better Health Care VI
dc.rights© 2018, Society of Photo-Optical Instrumentation Engineers. All rights reserved.en
dc.subjectReflectance spectroscopyen
dc.subjectOptical diagnosticsen
dc.subjectOptical propertiesen
dc.subjectDiffuse reflectanceen
dc.subjectOptical spectroscopyen
dc.titleDiffuse reflectance spectroscopy for determination of optical properties and chromophore concentrations of mice internal organs in the range of 350 nm to 1860 nmen
dc.typeConference itemen
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