Radiologic imaging in cystic fibrosis: cumulative effective dose and changing trends over 2 decades

Simple item page
dc.contributor.authorO'Connell, Oisin J.
dc.contributor.authorMcWilliams, Sebastian R.
dc.contributor.authorMcGarrigle, Anne Marie
dc.contributor.authorO'Connor, Owen J.
dc.contributor.authorShanahan, Fergus
dc.contributor.authorMullane, David
dc.contributor.authorEustace, Joseph A.
dc.contributor.authorMaher, Michael M.
dc.contributor.authorPlant, Barry J.
dc.date.accessioned2018-08-15T10:56:20Z
dc.date.available2018-08-15T10:56:20Z
dc.date.issued2015-12-16
dc.date.updated2012-09-26T14:40:29Z
dc.description.abstractObjective: With the increasing life expectancy for patients with cystic fibrosis (CF), and a known predisposition to certain cancers, cumulative radiation exposure from radiologic imaging is of increasing significance. This study explores the estimated cumulative effective radiation dose over a 17-year period from radiologic procedures and changing trends of imaging modalities over this period. Methods: Estimated cumulative effective dose (CED) from all thoracic and extrathoracic imaging modalities and interventional radiology procedures for both adult and pediatric patients with CF, exclusively attending a nationally designated CF center between 1992-2009 for > 1 year, was determined. The study period was divided into three equal tertiles, and estimated CED attributable to all radiologic procedures was estimated for each tertile. Results: Two hundred thirty patients met inclusion criteria (2,240 person-years of follow-up; 5,596 radiologic procedures). CED was > 75 mSv for one patient (0.43%), 36 patients (15.6%) had a CED between 20 and 75 mSv, 56 patients (24.3%) had a CED between 5 and 20 mSv, and in 138 patients (60%) the CED was estimated to be between 0 and 5 mSv over the study period. The mean annual CED per patient increased consecutively from 0.39 mSv/y to 0.47 mSv/y to 1.67 mSv/y over the tertiles one to three of the study period, respectively (P < .001). Thoracic imaging accounted for 46.9% of the total CED and abdominopelvic imaging accounted for 42.9% of the CED, respectively. There was an associated 5.9-fold increase in the use of all CT scanning per patient (P < .001). Conclusions: This study highlights the increasing exposure to ionizing radiation to patients with CF as a result of diagnostic imaging, primarily attributable to CT scanning. Increased awareness of CED and strategies to reduce this exposure are needed.en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationO'Connell, O. J., McWilliams, S., McGarrigle, A., O'Connor, O. J., Shanahan, F., Mullane, D., Eustace, J., Maher, M. M. and Plant, B. J. (2012) 'Radiologic Imaging in Cystic Fibrosis: Cumulative Effective Dose and Changing Trends Over 2 Decades', Chest, 141(6), pp. 1575-1583. doi: 10.1378/chest.11-1972en
dc.identifier.doi10.1378/chest.11-1972
dc.identifier.endpage1583en
dc.identifier.issn0012-3692
dc.identifier.issued6en
dc.identifier.journaltitleChesten
dc.identifier.startpage1575en
dc.identifier.urihttps://hdl.handle.net/10468/6613
dc.identifier.volume141en
dc.language.isoenen
dc.publisherElsevieren
dc.relation.urihttp://www.sciencedirect.com/science/article/pii/S0012369212603481
dc.rights© 2012 American College of Chest Physicians. Published by Elsevier. This accepted manuscript version is made available under the CC-BY-NC-ND 4.0 license.en
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectComputer assisted tomographyen
dc.subjectBarium mealen
dc.subjectCorrelation analysisen
dc.subjectCystic fibrosisen
dc.subjectDiagnostic imagingen
dc.subjectEchographyen
dc.subjectFluoroscopy Forced expiratory volumeen
dc.subjectHigh resolution computer tomographyen
dc.subjectLung angiographyen
dc.subjectLung scintiscanningen
dc.subjectRadiation doseen
dc.subjectRadiation dose distributionen
dc.subjectRadiation exposureen
dc.subjectSpine radiographyen
dc.subjectThorax radiographyen
dc.titleRadiologic imaging in cystic fibrosis: cumulative effective dose and changing trends over 2 decadesen
dc.typeArticle (peer-reviewed)en
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
chest.11-1972.full.pdf
Size:
1.48 MB
Format:
Adobe Portable Document Format
Description:
Accepted version
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
2.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Medicine - Journal Articles