Exposure of children to rural lifestyle factors associated with protection against allergies induces an anti-Neu5Gc antibody response

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dc.contributor.authorFrei, Remo
dc.contributor.authorRoduit, Caroline
dc.contributor.authorFerstl, Ruth
dc.contributor.authorO'Mahony, Liam
dc.contributor.authorLauener, Roger P.
dc.contributor.funderChristine Kuehne-Center for Allergy Research and Education (CK-CARE), Switzerlanden
dc.date.accessioned2019-11-06T10:22:14Z
dc.date.available2019-11-06T10:22:14Z
dc.date.issued2019-07-16
dc.description.abstractRural lifestyle has been shown to be highly protective against the development of allergies. Contact to farm-animals or pets and early-life consumption of milk products that turned out to be important. These exposures provide contact to N-glycolylneuraminic acid (Neu5Gc), a sialic acid naturally expressed in mammalians but not in humans or microbes although both are able to incorporate exogenously provided Neu5Gc and induce thereby and anti-Neu5Gc antibody response. Farmers’ children had elevated levels of anti-Neu5Gc antibodies associated with increased contact to Neu5Gc. Farm-related exposures that were associated with protection against allergies such as exposure to farm-animals or pets and consumption of milk were also associated with an antibody response to Neu5Gc in children. Exposure to cats was associated with increased anit-Neu5Gc IgG levels at different timepoints assessed between one year of age and school-age. Moreover, consumption of non-pasteurized milk in the first year of life was associated with increased anti-Neu5Gc IgG levels. Neu5Gc-providing exposures that were associated with protection against allergies were reflected in an elevated anti-Neu5Gc IgG level in children. Exposure to Neu5Gc was associated with anti-inflammation and protection of asthma development in children and mice without contribution of anti-Neu5Gc antibodies.en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid1628en
dc.identifier.citationFrei, R., Roduit, C., Ferstl, R., O'Mahony, L. and Lauener, R. (2019) 'Exposure of children to rural lifestyle factors associated with protection against allergies induces an anti-Neu5Gc antibody response', Frontiers in Immunology, 10, 1628 (5pp). doi:10.3389/fimmu.2019.01628en
dc.identifier.doi10.3389/fimmu.2019.01628en
dc.identifier.eissn1664-3224
dc.identifier.endpage5en
dc.identifier.journaltitleFrontiers in Immunologyen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/8958
dc.identifier.volume10en
dc.language.isoenen
dc.publisherFrontiers Mediaen
dc.rights© 2019 Frei, Roduit, Ferstl, O'Mahony and Lauener. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectN-glycolyl neuraminic aciden
dc.subjectAsmthaen
dc.subjectRegulatory T (Treg) cellen
dc.subjectAnti-inflammationen
dc.subjectAnimal contacten
dc.subjectHygiene hypothesisen
dc.titleExposure of children to rural lifestyle factors associated with protection against allergies induces an anti-Neu5Gc antibody responseen
dc.typeArticle (peer-reviewed)en
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