Functional maturation in preterm infants measured by serial recording of cortical activity
dc.contributor.author | Stevenson, N. J. | |
dc.contributor.author | Oberdorfer, L. | |
dc.contributor.author | Koolen, N. | |
dc.contributor.author | O'Toole, John M. | |
dc.contributor.author | Werther, T. | |
dc.contributor.author | Klebermass-Schrehof, K. | |
dc.contributor.author | Vanhatalo, S. | |
dc.contributor.funder | Austrian Science Fund | |
dc.contributor.funder | Sigrid JusƩliuksen SƤƤtiƶ | |
dc.contributor.funder | Academy of Finland | |
dc.contributor.funder | Science Foundation Ireland | |
dc.contributor.funder | Irish Research Council | |
dc.contributor.funder | Suomen Kulttuurirahasto | |
dc.contributor.funder | Horizon 2020 Framework Programme | |
dc.date.accessioned | 2017-12-08T13:33:42Z | |
dc.date.available | 2017-12-08T13:33:42Z | |
dc.date.issued | 2017-10-11 | |
dc.description.abstract | Minimally invasive, automated cot-side tools for monitoring early neurological development can be used to guide individual treatment and benchmark novel interventional studies. We develop an automated estimate of the EEG maturational age (EMA) for application to serial recordings in preterm infants. The EMA estimate was based on a combination of 23 computational features estimated from both the full EEG recording and a period of low EEG activity (46 features in total). The combination function (support vector regression) was trained using 101 serial EEG recordings from 39 preterm infants with a gestational age less than 28 weeks and normal neurodevelopmental outcome at 12 months of age. EEG recordings were performed from 24 to 38 weeks post-menstrual age (PMA). The correlation between the EMA and the clinically determined PMA at the time of EEG recording was 0.936 (95%CI: 0.932ā0.976; nā=ā39). All infants had an increase in EMA between the first and last EEG recording and 57/62 (92%) of repeated measures within an infant had an increasing EMA with PMA of EEG recording. The EMA is a surrogate measure of age that can accurately determine brain maturation in preterm infants. | en |
dc.description.sponsorship | Irish Research Council (GOIPD/2014/396); Science Foundation Ireland (15/SIRG/3580); Academy of Finland (253130); Austrian Science Fund (Fonds zur Fƶrderung der Wissenschaftlichen Forschung) (FWF KLI 237) | en |
dc.description.status | Peer reviewed | en |
dc.description.version | Published Version | en |
dc.format.mimetype | application/pdf | en |
dc.identifier.articleid | 12969 | |
dc.identifier.citation | Stevenson, N. J., Oberdorfer, L., Koolen, N., OāToole, J. M., Werther, T., Klebermass-Schrehof, K. and Vanhatalo, S. (2017) 'Functional maturation in preterm infants measured by serial recording of cortical activity', Scientific Reports, 7, 12969 (7pp). doi:10.1038/s41598-017-13537-3 | en |
dc.identifier.doi | 10.1038/s41598-017-13537-3 | |
dc.identifier.endpage | 7 | |
dc.identifier.issn | 2045-2322 | |
dc.identifier.journaltitle | Scientific Reports | en |
dc.identifier.startpage | 1 | |
dc.identifier.uri | https://hdl.handle.net/10468/5138 | |
dc.identifier.volume | 7 | |
dc.language.iso | en | en |
dc.publisher | Nature Publishing Group | en |
dc.relation.project | info:eu-repo/grantAgreement/EC/H2020::MSCA-IF-EF-ST/656131/EU/An analyzer for preterm EEG/APE | |
dc.relation.uri | https://www.nature.com/articles/s41598-017-13537-3 | |
dc.rights | Ā© 2017, the Authors 2017. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the articleās Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the articleās Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. | en |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.subject | Diagnostic markers | en |
dc.subject | Paediatric research | en |
dc.title | Functional maturation in preterm infants measured by serial recording of cortical activity | en |
dc.type | Article (peer-reviewed) | en |