Multi-population cohort meta-analysis of human intestinal microbiota in early life reveals the existence of infant community state types (ICSTs)

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dc.contributor.authorMancabelli, Leonardoen
dc.contributor.authorTarracchini, Chiaraen
dc.contributor.authorMilani, Christianen
dc.contributor.authorLugli, Gabriele Andreaen
dc.contributor.authorFontana, Federicoen
dc.contributor.authorTurroni, Francescaen
dc.contributor.authorvan Sinderen, Douween
dc.contributor.authorVentura, Marcoen
dc.contributor.funderEuropean Commissionen
dc.contributor.funderGenProbioen
dc.contributor.funderScience Foundation Irelanden
dc.date.accessioned2023-11-13T18:24:29Z
dc.date.available2023-11-13T18:24:29Z
dc.date.issued2020-01-01en
dc.description.abstractAppropriate development of the intestinal microbiota during infancy is known to be important for human health. In fact, aberrant alterations of the microbial composition during childhood may cause short- and/or long-term negative health effects. Many factors influence the initial assembly and subsequent progression of the gut microbiota of a neonate, such as feeding type, delivery mode, gestational age, maternal metabolic status and antibiotic exposure. In the current study, the composition of the infant gut core-microbiota was explored, revealing particular variations of this core-microbiota during the first three years as influenced by delivery mode and feeding type. A multi-population cohort meta-analysis was performed by selecting 15 publicly available datasets pertaining to taxonomic profiles of 1035 fecal samples of healthy infants, as obtained by means of a 16S rRNA gene-based profiling approach. Interestingly, this multi-population cohort meta-analysis revealed great microbial complexity and specific taxonomic shifts in children older than six months, suggesting a major impact by the introduction of solid foods which prompts progression of infant gut microbiota towards that typical of adults. The taxonomic data sets employed in this multi-population cohort meta-analysis possess the statistical robustness to allow the identification of infant community state types (ICSTs). Our analysis therefore reveals the existence of specific taxonomic patterns that correspond to particular nutritional and developmental stages of early life, and that had previously been obscured by the high variability typical of such infant gut microbiota.en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationMancabelli, L., Tarracchini, C., Milani, C., Lugli, G.A., Fontana, F., Turroni, F., Van Sinderen, D. and Ventura, M. (2020) ‘Multi-population cohort meta-analysis of human intestinal microbiota in early life reveals the existence of infant community state types (Icsts)’, Computational and Structural Biotechnology Journal, 18, pp. 2480–2493. doi: 10.1016/j.csbj.2020.08.028.en
dc.identifier.doi10.1016/j.csbj.2020.08.028en
dc.identifier.endpage2493en
dc.identifier.issn2001-0370en
dc.identifier.journaltitleComputational and Structural Biotechnology Journalen
dc.identifier.startpage2480en
dc.identifier.urihttps://hdl.handle.net/10468/15226
dc.identifier.volume18en
dc.language.isoenen
dc.publisherElsevieren
dc.relation.ispartofComputational and Structural Biotechnology Journalen
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/EU Joint Programming Initiative::A Healthy Diet for a Healthy Life JPI (HDHL-JPI)/15/JP-HDHL/3280/IE/Impact of early life on microbiome development and later health (EarlyMicroHealth)/en
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/en
dc.rights© 2020 The Authors. Published by Elsevier B.V. on behalf of Research Network of Computational and Structural Biotechnology. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectMetagenomicsen
dc.subject16S rRNA profilingen
dc.subjectCommunity state typesen
dc.subject~Microbiology - Journal Articles~en
dc.titleMulti-population cohort meta-analysis of human intestinal microbiota in early life reveals the existence of infant community state types (ICSTs)en
dc.typeArticle (peer-reviewed)en
dc.typejournal-articleen
oaire.citation.volume18en
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