Alkyl polyglucoside vs. ethoxylated surfactant-based microemulsions as vehicles for two poorly water-soluble drugs: physicochemical characterization and in vivo skin performance

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dc.contributor.authorPajic, Natasa Z. Bubic
dc.contributor.authorTodosijevic, Marija N.
dc.contributor.authorVuleta, Gordana M.
dc.contributor.authorCekic, Nebojsa D.
dc.contributor.authorDobricic, Vladimir D.
dc.contributor.authorVucen, Sonja R.
dc.contributor.authorCalija, Bojan R.
dc.contributor.authorLukic, Milica Z.
dc.contributor.authorIlic, Tanja M.
dc.contributor.authorSavic, Snezana D.
dc.contributor.funderMinistarstvo Prosvete, Nauke i Tehnološkog Razvoja
dc.date.accessioned2018-02-20T13:24:11Z
dc.date.available2018-02-20T13:24:11Z
dc.date.issued2017
dc.description.abstractTwo types of biocompatible surfactants were evaluated for their capability to formulate skin-friendly/non-irritant microemulsions as vehicles for two poorly water-soluble model drugs differing in properties and concentrations: alkyl polyglucosides (decyl glucoside and caprylyl/capryl glucoside) and ethoxylated surfactants (glycereth-7-caprylate/caprate and polysorbate 80). Phase behavior, structural inversion and microemulsion solubilization potential for sertaconazole nitrate and adapalene were found to be highly dependent on the surfactants structure and HLB value. Performed characterization (polarized light microscopy, pH, electrical conductivity, rheological, FTIR and DSC measurements) indicated a formulation containing glycereth-7-caprylate/caprate as suitable for incorporation of both drugs, whereas alkyl polyglucoside-based systems did not exhibit satisfying solubilization capacity for sertaconazole nitrate. Further, monitored parameters were strongly affected by sertaconazole nitrate incorporation, while they remained almost unchanged in adapalene-loaded vehicles. In addition, results of the in vivo skin performance study supported acceptable tolerability for all investigated formulations, suggesting selected microemulsions as promising carriers worth exploring further for effective skin delivery of model drugs.en
dc.description.sponsorshipMinistarstvo Prosvete, Nauke i Tehnološkog Razvoja (Project TR34031)en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationPajić Nataša, Z. B., Todosijević Marija, N., Vuleta Gordana, M., Cekić Nebojša, D., Dobričić Vladimir, D., Vučen Sonja, R., Čalija Bojan, R., Lukić Milica, Ž., Ilić Tanja, M. and Savić Snežana, D. (2017). 'Alkyl polyglucoside vs. ethoxylated surfactant-based microemulsions as vehicles for two poorly water-soluble drugs: physicochemical characterization and in vivo skin performance', Acta Pharmaceutica, 67(4), pp. 415–439. doi: 10.1515/acph-2017-0036en
dc.identifier.doi10.1515/acph-2017-0036
dc.identifier.endpage439
dc.identifier.issn1330-0075
dc.identifier.issued4
dc.identifier.journaltitleActa Pharmaceuticaen
dc.identifier.startpage415
dc.identifier.urihttps://hdl.handle.net/10468/5493
dc.identifier.volume67
dc.language.isoenen
dc.publisherDe Gruyter Openen
dc.relation.urihttps://www.degruyter.com/view/j/acph.2017.67.issue-4/acph-2017-0036/acph-2017-0036.xml
dc.rights© 2018, the Authors. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License. BY-NC-ND 4.0en
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectPhase behavioren
dc.subjectDeliveryen
dc.subjectFormulationen
dc.subjectParametersen
dc.subjectTransporten
dc.subjectSystemsen
dc.subjectAciden
dc.titleAlkyl polyglucoside vs. ethoxylated surfactant-based microemulsions as vehicles for two poorly water-soluble drugs: physicochemical characterization and in vivo skin performanceen
dc.typeArticle (peer-reviewed)en
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