PEGylated gold nanoparticles: polymer quantification as a function of PEG lengths and nanoparticle dimensions

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dc.contributor.authorRahme, Kamil
dc.contributor.authorHobbs, Richard G.
dc.contributor.authorChen, Lan
dc.contributor.authorMorris, Michael A.
dc.contributor.authorO'Driscoll, Caitríona M.
dc.contributor.authorHolmes, Justin D.
dc.contributor.funderHigher Education Authorityen
dc.contributor.funderScience Foundation Irelanden
dc.date.accessioned2016-02-15T14:28:09Z
dc.date.available2016-02-15T14:28:09Z
dc.date.issued2013-02-14
dc.date.updated2013-08-20T17:02:51Z
dc.description.abstractAu nanoparticles with diameters ranging between 15 and 170 nm have been synthesised in aqueous solution using a seed-mediated growth method, employing hydroxylamine hydrochloride as a reducing agent. Thiolated polyethylene glycol (mPEG-SH) polymers, with molecular weights ranging from 2100 to 51 000 g mol-1, were used as efficient particle stabilising ligands. Dynamic light scattering and zeta potential measurements confirmed that the overall mean diameter and zeta potential of the capped nanoparticles increased in a non-linear way with increasing molecular weight of the mPEG-SH ligand. Electron microscopy and thermal gravimetric analysis of the polymer-capped nanoparticles, with a mean gold core diameter of 15 nm, revealed that the grafting density of the mPEG-SH ligands decreased from 3.93 to 0.31 PEG nm-2 as the molecular weight of the ligands increased from 2100 to 51 400 g mol-1 respectively, due to increased steric hindrance and polymer conformational entropy with increase in the PEG chain length. Additionally, the number of bound mPEG-SH ligands, with a molecular weight of 10 800 g mol-1, was found to increase in a non-linear way from 278 (σ = 42) to approximately 12 960 PEG (σ = 1227) when the mean Au core diameter increased from 15 to 115 nm respectively. However, the grafting density of mPEG10 000-SH ligands was higher on 15 nm Au nanoparticles and decreased slightly from 1.57 to 0.8 PEG nm-2 when the diameter increased; this effect can be attributed to the fact that smaller particles offer higher surface curvature, therefore allowing increased polymer loading per nm2. Au nanoparticles were also shown to interact with CT-26 cells without causing noticeable toxicity.en
dc.description.sponsorshipScience Foundation Ireland (Grant 07/SRC/B1155 and 07/SRC/B1154 to the Irish Drug Delivery network (IDDN) through Strategic Research Cluster (SRC) grants); Higher Education Authority (HEA Program for Research in Third Level Institutions (2007-2011) INSPIRE)en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationRAHME, K., CHEN, L., HOBBS, R. G., MORRIS, M. A., O'DRISCOLL, C. & HOLMES, J. D. 2013. PEGylated gold nanoparticles: polymer quantification as a function of PEG lengths and nanoparticle dimensions. RSC Advances, 3, 6085-6094. http://dx.doi.org/10.1039/C3RA22739Aen
dc.identifier.doi10.1039/C3RA22739A
dc.identifier.endpage6094en
dc.identifier.issn2046-2069
dc.identifier.issued17en
dc.identifier.journaltitleRSC Advancesen
dc.identifier.startpage6085en
dc.identifier.urihttps://hdl.handle.net/10468/2287
dc.identifier.volume3en
dc.language.isoenen
dc.publisherThe Royal Society of Chemistryen
dc.relation.urihttp://pubs.rsc.org/en/content/articlepdf/2013/ra/c3ra22739a
dc.rights© Royal Society of Chemistry 2013.en
dc.subjectConformational entropyen
dc.subjectGold Nanoparticlesen
dc.subjectGrafting densitiesen
dc.subjectHydroxylamine hydrochlorideen
dc.subjectSeed-mediated growth methodsen
dc.subjectSurface curvaturesen
dc.subjectThermal gravimetric analysisen
dc.subjectZeta potential measurementsen
dc.subjectChain lengthen
dc.subjectElectron microscopyen
dc.subjectGrafting (chemical)en
dc.subjectLigandsen
dc.subjectMolecular weighten
dc.subjectNanoparticlesen
dc.subjectPolyethylene glycolsen
dc.subjectPolyethylene oxidesen
dc.subjectPolymersen
dc.subjectThermogravimetric analysisen
dc.subjectZeta potentialen
dc.subjectGolden
dc.subject~Chemistry - Journal Articles~en
dc.subject~Pharmacy - Journal Articles~en
dc.titlePEGylated gold nanoparticles: polymer quantification as a function of PEG lengths and nanoparticle dimensionsen
dc.typeArticle (peer-reviewed)en
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