Access to this article is restricted until 12 months after publication by request of the publisher.. Restriction lift date: 2022-05-08
Biobetters in patients with immune-mediated inflammatory disorders: An international Delphi consensus
dc.check.date | 2022-05-08 | |
dc.check.info | Access to this article is restricted until 12 months after publication by request of the publisher. | en |
dc.contributor.author | D'Amico, Ferdinando | |
dc.contributor.author | Solitano, Virginia | |
dc.contributor.author | Aletaha, Daniel | |
dc.contributor.author | Hart, Ailsa | |
dc.contributor.author | Magro, Fernando | |
dc.contributor.author | Selmi, Carlo | |
dc.contributor.author | Ng, Siew C. | |
dc.contributor.author | Al Awadhi, Sameer | |
dc.contributor.author | Choy, Ernest | |
dc.contributor.author | Schulze-Koops, Hendrik | |
dc.contributor.author | Bossuyt, Peter | |
dc.contributor.author | Olivera, Pablo A. | |
dc.contributor.author | Kotze, Paulo Gustavo | |
dc.contributor.author | Ghosh, Subrata | |
dc.contributor.author | Peyrin-Biroulet, Laurent | |
dc.contributor.author | Danese, Silvio | |
dc.contributor.funder | Celltrion Healthcare | en |
dc.date.accessioned | 2021-07-05T10:27:50Z | |
dc.date.available | 2021-07-05T10:27:50Z | |
dc.date.issued | 2021-05-08 | |
dc.date.updated | 2021-07-05T09:59:50Z | |
dc.description.abstract | Several efforts have been made to improve the available therapeutic armamentarium of patients with immune-mediated inflammatory disorders (IMIDs) leading to the development of biobetters. To date, there is no commonly accepted definition of biobetters. Sixteen physicians with expertise in the field of IMIDs from eleven countries attended a virtual international consensus meeting to provide for the first time a definition of biobetter and to identify unmet needs on this topic. Improvements in clinical outcomes and drug pharmacology were considered crucial for the definition of biobetters, while safety profile and patient acceptability were not. In addition, an appropriate balance between clinical outcomes and costs and a shared decision between physicians and patients should guide the decision to use a biobetter. Clinical studies are required to validate the biobetter definition and to investigate their role in the management of patients with IMIDs. | en |
dc.description.status | Peer reviewed | en |
dc.description.version | Accepted Version | en |
dc.format.mimetype | application/pdf | en |
dc.identifier.articleid | 102849 | en |
dc.identifier.citation | D'Amico, F., Solitano, V., Aletaha, D., Hart, A., Magro, F., Selmi, C., Ng, S. C., Al Awadhi, S., Choy, E., Schulze-Koops, H., Bossuyt, P., Olivera, P. A., Kotze, P. G., Ghosh, S., Peyrin-Biroulet, L. and Danese, S. (2021) 'Biobetters in patients with immune-mediated inflammatory disorders: An international Delphi consensus', Autoimmunity Reviews, 20(7), 102849 (7pp). doi: 10.1016/j.autrev.2021.102849 | en |
dc.identifier.doi | 10.1016/j.autrev.2021.102849 | en |
dc.identifier.endpage | 7 | en |
dc.identifier.issn | 1873-0183 | |
dc.identifier.issn | 1568-9972 | |
dc.identifier.issued | 7 | en |
dc.identifier.journaltitle | Autoimmunity Reviews | en |
dc.identifier.startpage | 1 | en |
dc.identifier.uri | https://hdl.handle.net/10468/11534 | |
dc.identifier.volume | 20 | en |
dc.language.iso | en | en |
dc.publisher | Elsevier B.V. | en |
dc.rights | © 2021, Elsevier B.V. All rights reserved. This manuscript version is made available under the CC BY-NC-ND 4.0 license. | en |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | en |
dc.subject | Immune-mediated inflammatory disorders | en |
dc.subject | Biobetters | en |
dc.subject | Definition | en |
dc.subject | Consensus | en |
dc.title | Biobetters in patients with immune-mediated inflammatory disorders: An international Delphi consensus | en |
dc.type | Article (peer-reviewed) | en |
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