Biobetters in patients with immune-mediated inflammatory disorders: An international Delphi consensus

dc.check.date2022-05-08
dc.check.infoAccess to this article is restricted until 12 months after publication by request of the publisher.en
dc.contributor.authorD'Amico, Ferdinando
dc.contributor.authorSolitano, Virginia
dc.contributor.authorAletaha, Daniel
dc.contributor.authorHart, Ailsa
dc.contributor.authorMagro, Fernando
dc.contributor.authorSelmi, Carlo
dc.contributor.authorNg, Siew C.
dc.contributor.authorAl Awadhi, Sameer
dc.contributor.authorChoy, Ernest
dc.contributor.authorSchulze-Koops, Hendrik
dc.contributor.authorBossuyt, Peter
dc.contributor.authorOlivera, Pablo A.
dc.contributor.authorKotze, Paulo Gustavo
dc.contributor.authorGhosh, Subrata
dc.contributor.authorPeyrin-Biroulet, Laurent
dc.contributor.authorDanese, Silvio
dc.contributor.funderCelltrion Healthcareen
dc.date.accessioned2021-07-05T10:27:50Z
dc.date.available2021-07-05T10:27:50Z
dc.date.issued2021-05-08
dc.date.updated2021-07-05T09:59:50Z
dc.description.abstractSeveral efforts have been made to improve the available therapeutic armamentarium of patients with immune-mediated inflammatory disorders (IMIDs) leading to the development of biobetters. To date, there is no commonly accepted definition of biobetters. Sixteen physicians with expertise in the field of IMIDs from eleven countries attended a virtual international consensus meeting to provide for the first time a definition of biobetter and to identify unmet needs on this topic. Improvements in clinical outcomes and drug pharmacology were considered crucial for the definition of biobetters, while safety profile and patient acceptability were not. In addition, an appropriate balance between clinical outcomes and costs and a shared decision between physicians and patients should guide the decision to use a biobetter. Clinical studies are required to validate the biobetter definition and to investigate their role in the management of patients with IMIDs.en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid102849en
dc.identifier.citationD'Amico, F., Solitano, V., Aletaha, D., Hart, A., Magro, F., Selmi, C., Ng, S. C., Al Awadhi, S., Choy, E., Schulze-Koops, H., Bossuyt, P., Olivera, P. A., Kotze, P. G., Ghosh, S., Peyrin-Biroulet, L. and Danese, S. (2021) 'Biobetters in patients with immune-mediated inflammatory disorders: An international Delphi consensus', Autoimmunity Reviews, 20(7), 102849 (7pp). doi: 10.1016/j.autrev.2021.102849en
dc.identifier.doi10.1016/j.autrev.2021.102849en
dc.identifier.endpage7en
dc.identifier.issn1873-0183
dc.identifier.issn1568-9972
dc.identifier.issued7en
dc.identifier.journaltitleAutoimmunity Reviewsen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/11534
dc.identifier.volume20en
dc.language.isoenen
dc.publisherElsevier B.V.en
dc.rights© 2021, Elsevier B.V. All rights reserved. This manuscript version is made available under the CC BY-NC-ND 4.0 license.en
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectImmune-mediated inflammatory disordersen
dc.subjectBiobettersen
dc.subjectDefinitionen
dc.subjectConsensusen
dc.titleBiobetters in patients with immune-mediated inflammatory disorders: An international Delphi consensusen
dc.typeArticle (peer-reviewed)en
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