Hyponatremia and hypercalcemia: a study of a large cohort of patients with lung cancer

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dc.contributor.authorChan, Vanessa W. Q.
dc.contributor.authorHenry, Michael T.
dc.contributor.authorKennedy, Marcus P.
dc.date.accessioned2020-02-25T12:24:10Z
dc.date.available2020-02-25T12:24:10Z
dc.date.issued2019-10-11
dc.description.abstractBackground: Hyponatremia and hypercalcemia are reported to be associated with poorer prognosis in lung cancer. Our study assessed the incidence of hyponatremia and hypercalcemia in a recent large cohort of patients diagnosed with lung cancer in an academic institution and correlated incidence with patient and tumour parameters. Methods: All patients presented at our regional lung cancer multidisciplinary team meeting between January 2011 and December 2016 were included. The incidence of hyponatremia (serum sodium ≤135 mEq/L) and hypercalcemia (serum calcium >2.62 mmol/L), including severity (mild, moderate or severe) was evaluated and stratified by tumour subtype and stage, and correlated with patient parameters. Results: A total of 624 patients (mean age, 67.4 years; 59.3% male) diagnosed with tissue-proven lung cancer were included. Hyponatremia and hypercalcemia were present in 31.6% (n=197) and 7.1% (n=44) at time of diagnosis. Hyponatremia occurred most commonly in patients with small cell lung carcinoma (SCLC) (n=42; 41.2%; P=0.001). Hypercalcemia occurred most commonly in patients with non-small cell lung carcinoma (NSCLC) squamous subtype (n=27; 12.2%; P=0.003). The incidence of hyponatremia and hypercalcemia were significantly higher in the advanced stages (P<0.041), except in SCLC where no difference in hypercalcemia incidence across the stages was observed (P=0.573). The Eastern Cooperative Oncology Group Performance Status (ECOG-PS) score was positively correlated with severity of hyponatremia at the early stage of NSCLC (Spearman correlation coefficient =0.325; P=0.003). Conclusions: Hyponatremia is a common association in lung cancer, especially in SCLC. Hypercalcemia is an uncommon but significant association in the NSCLC squamous subtype. Hyponatremia might contribute to poorer ECOG-PS scores at the early stage of NSCLC.en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationChan, V. W. Q., Henry, M. T. and Kennedy, M. P. (2019) ‘Hyponatremia and hypercalcemia: a study of a large cohort of patients with lung cancer’, Translational Cancer Research, 9(1), pp. 222-230. doi: 10.21037/tcr.2019.12.72en
dc.identifier.doi10.21037/tcr.2019.12.72en
dc.identifier.eissn2219-6803
dc.identifier.endpage230en
dc.identifier.issn2218-676X
dc.identifier.issued1en
dc.identifier.journaltitleTranslational Cancer Researchen
dc.identifier.startpage222en
dc.identifier.urihttps://hdl.handle.net/10468/9697
dc.identifier.volume9en
dc.language.isoenen
dc.publisherAME Publishing Companyen
dc.relation.urihttp://tcr.amegroups.com/article/view/35140/html
dc.rights© 2019, Translational Cancer Research. All rights reserved.en
dc.subjectEpidemiologyen
dc.subjectHyponatremiaen
dc.subjectHypercalcemiaen
dc.subjectSmall cell lung canceren
dc.subjectNon-small cell lung canceren
dc.titleHyponatremia and hypercalcemia: a study of a large cohort of patients with lung canceren
dc.typeArticle (peer-reviewed)en
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