Multimodal optical spectroscopic approach to design a complete protocol for early diagnosis of oral cancer

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dc.contributor.authorMaryam, Siddraen
dc.contributor.authorGhauri, M. Daniyalen
dc.contributor.authorFahy, Edwarden
dc.contributor.authorSekar, Sanathana Konugolu Venkataen
dc.contributor.authorLu, Huihuien
dc.contributor.authorRusso, Alidaen
dc.contributor.authorSaito Nogueira, Marceloen
dc.contributor.authorBurke, Rayen
dc.contributor.authorFeeley, Lindaen
dc.contributor.authorSheahen, Patricken
dc.contributor.authorNi Riordain, Richealen
dc.contributor.authorAndersson-Engels, Stefanen
dc.contributor.authorKho, Kiang Weien
dc.contributor.authorGautam, Rekhaen
dc.contributor.editorBoudoux, Carolineen
dc.contributor.editorTunnell, James W.en
dc.contributor.funderScience Foundation Irelanden
dc.date.accessioned2023-05-09T15:29:49Z
dc.date.available2023-05-09T15:29:49Z
dc.date.issued2023-03-06en
dc.description.abstractOral cancer is one of the most malignant cancers in the world. Early-stage diagnosis of oral cancer is complex process due to the multifocal unspecific development of non-malignant lesions into cancer and impossibility to take biopsy of every lesion. The aim of this study is to develop a screening method for oral cancer diagnosis at early stages using surface enhanced Raman spectroscopy (SERS) and validate the performance of a multimodal system including Raman spectroscopic (RS) and diffuse reflectance spectroscopy (DRS) oral cancer diagnosis and accurate margin detection. The study will involve the identification and integration of spectral biomarkers involved in the carcinogenesis process from different modalities. Each modality SERS, RS and DRS is calibrated and standardized individually. Patients suffering from oral squamous cell carcinoma and other malignant diseases going through biopsy or histopathological examination are enrolled in this study. Ex vivo study involves the SERS analysis of saliva specimen and in vivo analysis will involve measurements on various tissue types, including malignant tissue and healthy contralateral site to evaluate the reproducibility and signal-to-noise ratio using fiber-optic probes for Raman and DRS systems. Feature selection methods and further machine learning tools will be used to discriminate between healthy, benign and cancer lesions based on spectral information and to identify important biomarkers. After data collection, clinician will perform a normal biopsy procedure and histopathological analysis, which will serve as gold standard to determine the sensitivity and specificity of the spectroscopy techniques.en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid123680Oen
dc.identifier.citationMaryam, S., Ghauri, M. D., Fahy, E., Sekar, S. K. V., Lu, H., Russo, A., Saito Nogueira, M., Burke, R., Feeley, L., Sheahen, P., Ni Riordain, R., Andersson-Engels, S., Kho, K. W. and Gautam, R. (2023) 'Multimodal optical spectroscopic approach to design a complete protocol for early diagnosis of oral cancer', Proceedings of SPIE, 12368, Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XXI, 123680O (4pp). doi: 10.1117/12.2650536en
dc.identifier.doi10.1117/12.2650536en
dc.identifier.eissn1996-756Xen
dc.identifier.endpage4en
dc.identifier.issn0277-786Xen
dc.identifier.journaltitleProceedings of SPIEen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/14443
dc.identifier.volume12368en
dc.language.isoenen
dc.publisherSociety of Photo-Optical Instrumentation Engineers (SPIE)en
dc.relation.ispartofAdvanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XXIen
dc.relation.ispartofProgress in Biomedical Optics and Imaging Vol. 24 No. 17en
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Professorship Programme/15/RP/2828/IE/Novel applications and techniques for in vivo optical imaging and spectroscopy/en
dc.rights© 2023, Society of Photo-Optical Instrumentation Engineers. One print or electronic copy may be made for personal use only. Systematic reproduction and distribution, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited.en
dc.subjectOral canceren
dc.subjectScreeningen
dc.subjectSurface enhanced Raman spectroscopy (SERS)en
dc.titleMultimodal optical spectroscopic approach to design a complete protocol for early diagnosis of oral canceren
dc.typeConference itemen
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