Oleoylethanolamide treatment affects gut microbiota composition and the expression of intestinal cytokines in Peyer’s patches of mice

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dc.contributor.authorDi Paola, Monica
dc.contributor.authorBonechi, Elena
dc.contributor.authorProvensi, Gustavo
dc.contributor.authorCosta, Alessia
dc.contributor.authorClarke, Gerard
dc.contributor.authorBallerini, Clara
dc.contributor.authorDe Filippo, Carlotta
dc.contributor.authorPassani, M. Beatrice
dc.contributor.funderJoint Programming Initiative A healthy diet for a healthy lifeen
dc.contributor.funderConselho Nacional de Desenvolvimento Científico e Tecnológicoen
dc.contributor.funderMinistero della Saluteen
dc.contributor.funderBando Ricerca Finalizzataen
dc.contributor.funderGiovani Ricercatorien
dc.date.accessioned2019-10-02T04:36:26Z
dc.date.available2019-10-02T04:36:26Z
dc.date.issued2018-10-05
dc.description.abstractThe lipid sensor oleoylethanolamide (OEA), an endogenous high-affinity agonist of peroxisome proliferator-activated receptor-α (PPAR-α) secreted in the proximal intestine, is endowed with several distinctive homeostatic properties, such as control of appetite, anti-inflammatory activity, stimulation of lipolysis and fatty acid oxidation. When administered exogenously, OEA has beneficial effects in several cognitive paradigms; therefore, in all respects, OEA can be considered a hormone of the gut-brain axis. Here we report an unexplored modulatory effect of OEA on the intestinal microbiota and on immune response. Our study shows for the first time that sub-chronic OEA administration to mice fed a normal chow pellet diet, changes the faecal microbiota profile, shifting the Firmicutes:Bacteroidetes ratio in favour of Bacteroidetes (in particular Bacteroides genus) and decreasing Firmicutes (Lactobacillus), and reduces intestinal cytokines expression by immune cells isolated from Peyer’s patches. Our results suggest that sub-chronic OEA treatment modulates gut microbiota composition towards a “lean-like phenotype”, and polarises gut-specific immune responses mimicking the effect of a diet low in fat and high in polysaccharides content.en
dc.description.sponsorship201511/2014-2; GR-201102346829en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid14881en
dc.identifier.citationDi Paola, M., Bonechi, E., Provensi, G., Costa, A., Clarke, G., Ballerini, C., De Filippo, C. and Passani, M.B., 2018. Oleoylethanolamide treatment affects gut microbiota composition and the expression of intestinal cytokines in Peyer’s patches of mice. Scientific reports, 8(1), (14881). DOI:10.1038/s41598-018-32925-xen
dc.identifier.doi10.1038/s41598-018-32925-xen
dc.identifier.eissn2045-2322
dc.identifier.endpage12en
dc.identifier.issued1en
dc.identifier.journaltitleScientific Reportsen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/8658
dc.identifier.volume8en
dc.language.isoenen
dc.publisherSpringer Nature Limiteden
dc.relation.projectinfo:eu-repo/grantAgreement/RCUK/MRC/MR/N029488/1/GB/AMBROSIAC - A Menu for Brain Responses Opposing Stress-Induced Alterations in Cognition/en
dc.relation.urihttps://www.nature.com/articles/s41598-018-32925-x
dc.rights© The Author(s) 2018en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectOleoylethanolamide (OEA)en
dc.subjectPeroxisome proliferator-activated receptor-α (PPAR-α)en
dc.subjectProximal intestineen
dc.subjectCognitive paradigmsen
dc.titleOleoylethanolamide treatment affects gut microbiota composition and the expression of intestinal cytokines in Peyer’s patches of miceen
dc.typeArticle (peer-reviewed)en
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