Hydrogel-assisted neuroregeneration approaches towards brain injury therapy: A state-of-the-art review

Simple item page
dc.contributor.authorKornev, Vladimir A.
dc.contributor.authorGrebenik, Ekaterina A.
dc.contributor.authorSolovieva, Anna B.
dc.contributor.authorDmitriev, Ruslan I.
dc.contributor.authorTimashev, Peter S.
dc.contributor.funderRussian Science Foundationen
dc.contributor.funderScience Foundation Irelanden
dc.contributor.funderMinistry of Education and Science of the Russian Federationen
dc.date.accessioned2019-08-07T08:16:09Z
dc.date.available2019-08-07T08:16:09Z
dc.date.issued2018-01-01
dc.description.abstractRecent years have witnessed the development of an enormous variety of hydrogel-based systems for neuroregeneration. Formed from hydrophilic polymers and comprised of up to 90% of water, these three-dimensional networks are promising tools for brain tissue regeneration. They can assist structural and functional restoration of damaged tissues by providing mechanical support and navigating cell fate. Hydrogels also show the potential for brain injury therapy due to their broadly tunable physical, chemical, and biological properties. Hydrogel polymers, which have been extensively implemented in recent brain injury repair studies, include hyaluronic acid, collagen type I, alginate, chitosan, methylcellulose, Matrigel, fibrin, gellan gum, self-assembling peptides and proteins, poly(ethylene glycol), methacrylates, and methacrylamides. When viewed as tools for neuroregeneration, hydrogels can be divided into: (1) hydrogels suitable for brain injury therapy, (2) hydrogels that do not meet basic therapeutic requirements and (3) promising hydrogels which meet the criteria for further investigations. Our analysis shows that fibrin, collagen I and self-assembling peptide-based hydrogels display very attractive properties for neuroregeneration.en
dc.description.sponsorshipRSF(17-15-01487); Ministry of Education and Science of the Russian Federation (Russian Academic Excellence Project ‘5-100’ (Section3))en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationKornev, V.A., Grebenik, E.A., Solovieva, A.B., Dmitriev, R.I. and Timashev, P.S., 2018. Hydrogel-assisted neuroregeneration approaches towards brain injury therapy: A state-of-the-art review. Computational and structural biotechnology journal. 16, 488-502 DOI:10.1016/j.csbj.2018.10.011en
dc.identifier.doi10.1016/j.csbj.2018.10.011en
dc.identifier.eissn2001-0370
dc.identifier.endpage502en
dc.identifier.journaltitleComputational and Structural Biotechnology Journalen
dc.identifier.startpage488en
dc.identifier.urihttps://hdl.handle.net/10468/8287
dc.identifier.volume16en
dc.language.isoenen
dc.publisherElsevier B.V.en
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Starting Investigator Research Grant (SIRG)/13/SIRG/2144/IE/Development of Bionic Sensor Materials for Metabolic Imaging in Regenerative Medicine/en
dc.relation.urihttps://www.sciencedirect.com/science/article/pii/S2001037018300977?via%3Dihub
dc.rights© 2018 The Author(s). Published by Elsevier B.V. on behalf of Research Network of Computational and Structural Biotechnology.en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectBiomaterialsen
dc.subjectBrain injuryen
dc.subjectHydrogelen
dc.subjectNerve tissue engineeringen
dc.subjectNeural stem cellsen
dc.subjectStrokeen
dc.titleHydrogel-assisted neuroregeneration approaches towards brain injury therapy: A state-of-the-art reviewen
dc.typeArticle (peer-reviewed)en
Files
Original bundle
Now showing 1 - 2 of 2
Thumbnail Image
Name:
1-s2.0-S2001037018300977-main.pdf
Size:
751.81 KB
Format:
Adobe Portable Document Format
Description:
Published version
Download
Thumbnail Image
Name:
1-s2.0-S2001037018300977-mmc1.pdf
Size:
157.81 KB
Format:
Adobe Portable Document Format
Description:
Supplementary file
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
2.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Biochemistry and Cell Biology - Journal Articles