Current uses of chlorhexidine for management of oral disease: a narrative review

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dc.check.date2021-10-17
dc.check.infoAccess to this article is restricted until 12 months after publication by request of the publisher.en
dc.contributor.authorBrookes, Zoe L. S.
dc.contributor.authorBescos, Raul
dc.contributor.authorBelfield, Louise A.
dc.contributor.authorAli, Kamran
dc.contributor.authorRoberts, Anthony
dc.date.accessioned2020-11-10T13:26:57Z
dc.date.available2020-11-10T13:26:57Z
dc.date.issued2020-10-17
dc.date.updated2020-11-10T13:15:17Z
dc.description.abstractObjectives: Chlorhexidine (CHX) is a commonly used antiseptic mouthwash, used by dental practitioners and the public, due to its antimicrobial effects. The aim of this article was to provide a narrative review of current antimicrobial uses of CHX relevant to dentistry in the context of oral diseases, highlighting need for further studies to support its safe and appropriate use. Study selection, data and sources: Randomised controlled trials, systematic reviews and national (UK and US) guidelines were consulted where available, with search terms for each subject category entered into MEDLINE, PubMed, Google Scholar and the Cochrane database. Results: Some evidence existed to support adjunctive short-term use of CHX to manage dental plaque, and reduce clinical symptoms of gingivitis, dry socket, as well as reduce aerosolisation of bacteria. However, use must be weighed alongside the less desirable effects of CHX, including extrinsic staining of teeth, antimicrobial resistance to antiseptic agents and the rare, but fatal, allergic reactions to CHX. Conversely, evidence for the effectiveness of chlorhexidine to manage or prevent periodontitis, dental caries, necrotising periodontal diseases, peri-implantitis, and infections associated with extraction and aerosolised viruses remains less certain. Conclusions: The use of CHX in dentistry and oral healthcare continues to be widespread and thus it is important that dental practitioners understand that, based on its differential mechanisms of action on different microbes, appropriate clinical and dental use of CHX should be oral disease specific. However, further scientific and clinical research is required before full recommendations can be made.en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid103497en
dc.identifier.citationBrookes, Z. L. S., Bescos, R., Belfield, L. A., Ali, K. and Roberts, A.(2020) 'Current uses of chlorhexidine for management of oral disease: a narrative review', Journal of Dentistry, 103, 103497 (9pp). doi: 10.1016/j.jdent.2020.103497en
dc.identifier.doi10.1016/j.jdent.2020.103497en
dc.identifier.endpage9en
dc.identifier.issn1879-176X
dc.identifier.issn0300-5712
dc.identifier.journaltitleJournal of Dentistryen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/10749
dc.identifier.volume103en
dc.language.isoenen
dc.publisherElsevier B.V.en
dc.rights© 2020, Elsevier B.V. All rights reserved. This manuscript version is made available under the CC BY-NC-ND 4.0 license.en
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectChlorhexidineen
dc.subjectMouthwashen
dc.subjectPeriodontitisen
dc.subjectCariesen
dc.subjectBacteriaen
dc.subjectVirusen
dc.titleCurrent uses of chlorhexidine for management of oral disease: a narrative reviewen
dc.typeArticle (peer-reviewed)en
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