Temporal stability and lack of variance in microbiome composition and functionality in fit recreational athletes

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dc.contributor.authorO' Donovan, Ciara M.en
dc.contributor.authorNori, Sai Ravi Chandraen
dc.contributor.authorShanahan, Fergusen
dc.contributor.authorCelentano, Gerardinaen
dc.contributor.authorMurphy, Thomas Brendanen
dc.contributor.authorCotter, Paul D.en
dc.contributor.authorSullivan, Orla O'en
dc.contributor.funderScience Foundation Irelanden
dc.date.accessioned2025-04-23T11:14:57Z
dc.date.available2025-04-23T11:14:57Z
dc.date.issued2025en
dc.description.abstractHuman gut microbiome composition and function is influenced by environmental and lifestyle factors, including exercise and fitness. We studied the composition and functionality of the faecal microbiome of recreational (non-elite) runners (n = 62) with serial shotgun metagenomics, at 4 time points over a 7-week period. Gut microbiome composition and function was stable over time. Grouping of samples on the basis of their fitness level (fair, good, excellent, and superior) or habitual training (low (4–6 h/week), medium (7–9 h/week), high (10–12 h/week), and extreme (13 + hours/week)) revealed no significant microbiome-related differences. Overall, the species Faecalibacterium prausnitzii, Blautia wexlerae, and Prevotella copri were the most abundant members of the gut microbiome. Analysis of co-abundance groups (CAGs) revealed no significant relationship between CAGs and fitness levels or training subgroups. Functional pathways were similar across all samples and timepoints with no clustering based on associated metadata. The most abundant genes identified within samples corresponded to pathways for nucleoside and nucleotide biosynthesis, amino acid biosynthesis, and cell wall biosynthesis. Collectively, these results describe the microbiome of active recreational runners and note temporal stability amongst participants. © The Author(s) 2025.en
dc.description.sponsorshipScience Foundation Ireland (SFI/12/RC/2273; 13/SIRG/2160; 11/PI/1137; 22/FFP-A/10364)en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid5619en
dc.identifier.citationO'Donovan, C. M., Nori, S. R. C., Shanahan, F., Celentano, G., Murphy, T. B., Cotter, P. D. and Sullivan, O. O. (2025) 'Temporal stability and lack of variance in microbiome composition and functionality in fit recreational athletes', Scientific Reports, 15(1), p.5619. https://doi.org/10.1038/s41598-025-88723-9en
dc.identifier.doi10.1038/s41598-025-88723-9en
dc.identifier.issn20452322en
dc.identifier.issued1
dc.identifier.journaltitleScientific Reportsen
dc.identifier.urihttps://hdl.handle.net/10468/17295
dc.identifier.volume15
dc.language.isoenen
dc.publisherNature Researchen
dc.relation.projectSFI/12/RC/2273; 13/SIRG/2160; 11/PI/1137; 22/FFP-A/10364en
dc.rights© 2025, the Author(s). Open Accessen
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectAthletesen
dc.subjectFaecal microbiomeen
dc.subjectFitnessen
dc.subjectRunningen
dc.titleTemporal stability and lack of variance in microbiome composition and functionality in fit recreational athletesen
dc.typeArticle (peer reviewed)en
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