Microbial therapeutics designed for infant health

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dc.contributor.authorWatkins, Claire
dc.contributor.authorStanton,Catherine
dc.contributor.authorRyan, Anthony C.
dc.contributor.authorRoss, R. Paul
dc.contributor.funderDepartment of Agriculture, Food and the Marine
dc.contributor.funderScience Foundation Ireland
dc.date.accessioned2017-12-08T13:33:47Z
dc.date.available2017-12-08T13:33:47Z
dc.date.issued2017-10-26
dc.description.abstractAcknowledgment of the gut microbiome as a vital asset to health has led to multiple studies attempting to elucidate its mechanisms of action. During the first year of life, many factors can cause fluctuation in the developing gut microbiome. Host genetics, maternal health status, mode of delivery, gestational age, feeding regime, and perinatal antibiotic usage, are known factors which can influence the development of the infant gut microbiome. Thus, the microbiome of vaginally born, exclusively breastfed infants at term, with no previous exposure to antibiotics, either directly or indirectly from the mother, is to be considered the “gold standard.” Moreover, the use of prebiotics as an aid for the development of a healthy gut microbiome is equally as important in maintaining gut homeostasis. Breastmilk, a natural prebiotic source, provides optimal active ingredients for the growth of beneficial microbial species. However, early life disorders such as necrotising enterocolitis, childhood obesity, and even autism have been associated with an altered/disturbed gut microbiome. Subsequently, microbial therapies have been introduced, in addition to suitable prebiotic ingredients, which when administered, may aid in the prevention of a microbial disturbance in the gastrointestinal tract. The aim of this mini-review is to highlight the beneficial effects of different probiotic and prebiotic treatments in early life, with particular emphasis on the different conditions which negatively impact microbial colonisation at birth.en
dc.description.sponsorshipDepartment of Agriculture Food and Marine (INFANTMET (Ref. No. 10FDairy; ToddlerFood (Ref. No. 14F821)en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid48
dc.identifier.citationWatkins, C., Stanton, C., Ryan, C. A. and Ross, R. P. (2017) 'Microbial therapeutics designed for infant health', Frontiers in Nutrition, 4, 48 (8pp). doi: 10.3389/fnut.2017.00048en
dc.identifier.doi10.3389/fnut.2017.00048
dc.identifier.endpage8
dc.identifier.issn2296-861X
dc.identifier.journaltitleFrontiers in Nutritionen
dc.identifier.startpage1
dc.identifier.urihttps://hdl.handle.net/10468/5152
dc.identifier.volume4
dc.language.isoenen
dc.publisherFrontiers Mediaen
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/
dc.relation.urihttps://www.frontiersin.org/articles/10.3389/fnut.2017.00048/full
dc.rights© 2017, Watkins, Stanton, Ryan and Ross. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectProbioticsen
dc.subjectPrebioticsen
dc.subjectGut microbiotaen
dc.subjectInfanten
dc.subjectHealthen
dc.titleMicrobial therapeutics designed for infant healthen
dc.typeArticle (peer-reviewed)en
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