The gut microbiome connects nutrition and human health

Simple item page
dc.check.date2025-12-04en
dc.check.infoAccess to this article is restricted until 6 months after publication by request of the publisheren
dc.contributor.authorSanz, Yolandaen
dc.contributor.authorCryan, John F.en
dc.contributor.authorDeschasaux-Tanguy, Mélanieen
dc.contributor.authorElinav, Eranen
dc.contributor.authorLambrecht, Rebekkaen
dc.contributor.authorVeiga, Patricken
dc.contributor.funderMinisterio de Ciencia, Innovación y Universidadesen
dc.contributor.funderAgence Nationale de la Rechercheen
dc.contributor.funderScience Foundation Irelanden
dc.contributor.funderSaks-Kavanaugh Foundationen
dc.contributor.funderSchweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschungen
dc.contributor.funderNovo Nordisk Fondenen
dc.contributor.funderAzrieli Foundationen
dc.date.accessioned2025-10-06T13:59:36Z
dc.date.available2025-10-06T13:59:36Z
dc.date.issued2025-06-04en
dc.description.abstractThe gut microbiome has an undeniable role in mediating the health effects of the diet, given its ability to co-digest nutrients and influence nutrient signalling to multiple organ systems. As a suboptimal diet is a major risk factor for and contributor to disease, understanding the multidirectional interactions between the food we eat, the gut microbiome and the different body organ systems is crucial from a public health perspective. Indeed, this research area is leading to the refinement of nutritional concepts and strategies to optimize health through diet. In this Review, we provide an update on how dietary patterns and food intake shape gut microbiome features, the mode of action of diet–microorganism interactions on the immune, nervous and cardiometabolic systems and how this knowledge could explain the heterogeneity of dietary responses, and support food-based dietary guidelines and medical and precision nutrition. Finally, we discuss the knowledge gaps and research efforts needed to progress towards the integration of microbiome science with more precise dietary advice to leverage the role of nutrition in human health.en
dc.description.sponsorshipMinisterio de Ciencia, Innovación y Universidades (Grant PID2023-150693OB-I00; Ref. CEX2021-001189-S); Agence Nationale de la Recherche (ANR-11-DPBS-0001; ANR-24-PESA-0005); Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (CRSII5_186346/NMS2068); European Union (Thrive and Nutriome Consortiums); Novo Nordisk Foundation (Microbiome Health Initiative). Azrieli Foundation (Azrieli Fellowship)en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationSanz, Y., Cryan, J. F., Deschasaux-Tanguy, M., Elinav, E., Lambrecht, R. and Veiga, P. (2025) 'The gut microbiome connects nutrition and human health', Nature Reviews Gastroenterology & Hepatology, 22, pp. 534–555. https://doi.org/10.1038/s41575-025-01077-5en
dc.identifier.doi10.1038/s41575-025-01077-5en
dc.identifier.eissn1759-5053en
dc.identifier.endpage555en
dc.identifier.issn1759-5045en
dc.identifier.journaltitleNature Reviews Gastroenterology & Hepatologyen
dc.identifier.startpage534en
dc.identifier.urihttps://hdl.handle.net/10468/17962
dc.identifier.volume22en
dc.language.isoenen
dc.publisherSpringer Natureen
dc.relation.ispartofNature Reviews Gastroenterology & Hepatologyen
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/Rapid Response Supplemental Grant for Displaced Researchers::Ukraine Extension Grant/12/RC/2273_P2 (S2)/IE/12/RC/2273_P2 Supplement/en
dc.rights© 2025, Springer Nature. This is a post-peer-review, pre-copyedit version of an article published in Nature Reviews Gastroenterology & Hepatology. The final authenticated version is available online at: https://doi.org/10.1038/s41575-025-01077-5en
dc.subjectDieten
dc.subjectMicrbiomeen
dc.subjectGut microbiomeen
dc.subjectImmune systemen
dc.subjectNervous systemen
dc.subjectCardiometabolic systemen
dc.subjectHuman healthen
dc.titleThe gut microbiome connects nutrition and human healthen
dc.typeArticle (peer-reviewed)en
dc.typejournal-articleen
oaire.citation.issue8en
oaire.citation.volume22en
Files
Original bundle
Now showing 1 - 2 of 2
Thumbnail Image
Name:
Sanz et al Nat Rev Gastro Hepat_For Repository.pdf
Size:
681.4 KB
Format:
Adobe Portable Document Format
Description:
Accepted Version
Download
Thumbnail Image
Name:
41575_2025_1077_MOESM1_ESM.pdf
Size:
542.12 KB
Format:
Adobe Portable Document Format
Description:
Supplementary Information
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
2.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
APC Microbiome Ireland - Journal Articles