Piezoelectric inkjet coating of injection moulded, reservoir-tipped microneedle arrays for transdermal delivery

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dc.check.date2020-06-04
dc.check.infoAccess to this article is restricted until 12 months after publication by request of the publisher.en
dc.contributor.authorO'Mahony, Conor
dc.contributor.authorBocchino, Andrea
dc.contributor.authorHaslinger, Michael J.
dc.contributor.authorBrandstätter, Stefan
dc.contributor.authorAußerhuber, Helene
dc.contributor.authorSchossleitner, Klaudia
dc.contributor.authorClover, Anthony J. P.
dc.contributor.authorFechtig, Daniel
dc.contributor.funderÖsterreichische Forschungsförderungsgesellschaften
dc.contributor.funderScience Foundation Irelanden
dc.contributor.funderHigher Education Authorityen
dc.contributor.funderEnterprise Irelanden
dc.date.accessioned2019-08-27T15:35:21Z
dc.date.available2019-08-27T15:35:21Z
dc.date.issued2019-06-04
dc.date.updated2019-08-27T15:24:08Z
dc.description.abstractCoated microneedles have significant potential for use in transdermal delivery applications. In this paper, we describe the fabrication of microneedle master templates using microstereolithography techniques and subsequently use a commercial injection moulding process to replicate these microneedles in biocompatible cyclic olefin polymer (COP) materials. Notably, the 475 μm-tall needle designs feature a shallow pit or reservoir at the tip, thereby providing both a target and holder for incoming droplets that are deposited using a piezoelectric inkjet printer. Using this design, no tilting or rotation of the needle array is required during the filling process. In the preliminary tests reported here, the reservoir is filled with a FITC-labelled dye that acts as a model drug, and ex vivo skin tests are used to verify skin penetration, the transfer of this model drug to the skin and to measure the reliability of the needles themselves. To our knowledge, this is the first time that such an inkjet-filled, reservoir-tipped microneedle has been demonstrated.en
dc.description.sponsorshipÖsterreichische Forschungsförderungsgesellschaft (Austrian Research Promotion Agency (FFG) and was conducted in the framework of the program ‘Production of the future’ (MicroNeedle, Grant 853482)); Science Foundation Ireland (INSIGHT Centre, by Enterprise Ireland (CF/2012/2339)); Higher Education Authority (under the Programme for Research in Third-Level Institutions)en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid85004en
dc.identifier.citationO’Mahony, C., Bocchino, A., Haslinger, M. J., Brandstätter, S., Außerhuber, H., Schossleitner, K., Clover, A. J. P. and Fechtig, D. (2019) 'Piezoelectric inkjet coating of injection moulded, reservoir-tipped microneedle arrays for transdermal delivery', Journal of Micromechanics and Microengineering, 29 (8), 085004 (8 pp). doi: 10.1088/1361-6439/ab222ben
dc.identifier.doi10.1088/1361-6439/ab222ben
dc.identifier.endpage8en
dc.identifier.issn0960-1317
dc.identifier.issued8en
dc.identifier.journaltitleJournal of Micromechanics and Microengineeringen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/8401
dc.identifier.volume29en
dc.language.isoenen
dc.publisherIOP Publishingen
dc.relation.urihttps://iopscience.iop.org/article/10.1088/1361-6439/ab222b/meta
dc.rights© 2019 IOP Publishing Ltd. This is an author-created, un-copyedited version of an article accepted for publication in Journal of Micromechanics and Microengineering. The publisher is not responsible for any errors or omissions in this version of the manuscript or any version derived from it. The Version of Record is available online at https://doi.org/10.1088/1361-6439/ab222b.en
dc.rights.urihttps://creativecommons.org/licences/by-nc-nd/3.0en
dc.subjectMicroneedlesen
dc.subjectInjection mouldingen
dc.subjectPiezoelectric inkjet dispensingen
dc.subjectbioMEMS,en
dc.subjectTransdermal drug delivery,en
dc.subjectMicrostereolithographyen
dc.titlePiezoelectric inkjet coating of injection moulded, reservoir-tipped microneedle arrays for transdermal deliveryen
dc.typeArticle (peer-reviewed)en
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