Prediction of delivering a small for gestational age infant and adverse perinatal outcome in women with suspected pre-eclampsia

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dc.contributor.authorGriffin, Melanie
dc.contributor.authorSeed, Paul T.
dc.contributor.authorDuckworth, Suzy
dc.contributor.authorNorth, Robyn
dc.contributor.authorMyers, Jenny
dc.contributor.authorMackillop, Lucy
dc.contributor.authorSimpson, Nigel
dc.contributor.authorWaugh, Jason
dc.contributor.authorAnumba, Dilly
dc.contributor.authorKenny, Louise C.
dc.contributor.authorRedman, Christopher W. G.
dc.contributor.authorShennan, Andrew H.
dc.contributor.authorChappell, Lucy C.
dc.contributor.funderTommy's Baby Charityen
dc.contributor.funderNational Institute for Health Researchen
dc.contributor.funderGuy's and St Thomas' NHS Foundation Trusten
dc.contributor.funderKings College Londonen
dc.contributor.funderScience Foundation Irelanden
dc.contributor.funderAction Medical Researchen
dc.date.accessioned2017-10-10T11:30:59Z
dc.date.available2017-10-10T11:30:59Z
dc.date.issued2017-04-12
dc.date.updated2017-06-16T14:39:33Z
dc.description.abstractObjective: To evaluate the test performance of 47 biomarkers and ultrasound parameters to predict subsequent delivery of an SGA infant and adverse perinatal outcome in women presenting with suspected preeclampsia. Methods: In a prospective, multicentre observational study, 47 biomarkers and ultrasound parameters were measured in 397 women presenting with suspected preterm preeclampsia, with the objective of evaluating them as predictors of subsequent delivery of an SGA infant and adverse perinatal outcome. Factor analysis and stepwise logistic regression were performed in two pre-specified groups. Results: In 274 women presenting at 20+0 to 34+6 weeks’ gestation (Group 1), 96 (35%) delivered an SGA infant <3rd customised birthweight centile (SGA-3). For prediction of SGA-3, low maternal Placental Growth Factor (PlGF) concentrations had a sensitivity of 93% (95%CI 84% to 98%) and negative predictive value (NPV) of 90% (95%CI 76% to 97%) compared to a sensitivity of 71% (95%CI 58% to 82%) and a NPV of 79% (95%CI 68% to 87%) for ultrasound parameters (estimated fetal weight or abdominal circumference <10th centile). No individual biomarker evaluated had superior performance to PlGF and combinations added only small increments to test performance. Similar results were found in 123 women presenting between 35+0 to 36+6 weeks’ gestation (Group 2). Conclusions: In women presenting with suspected preterm preeclampsia, measurement of PlGF offers a useful adjunct for identifying those at high risk of delivering an SGA infant, allowing appropriate surveillance and timely intervention.en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationGriffin, M., Seed, P. T., Duckworth, S., North, R., Myers, J., Mackillop, L., Simpson, N., Waugh, J., Anumba, D., Kenny, L. C., Redman, C. W. G., Shennan, A. H. and Chappell, L. C. (2017) 'Prediction of delivering a small for gestational age infant and adverse perinatal outcome in women with suspected pre-eclampsia', Ultrasound in Obstetrics & Gynecology, In Press. doi:10.1002/uog.17490en
dc.identifier.doi10.1002/uog.17490
dc.identifier.issn1469-0705
dc.identifier.journaltitleUltrasound In Obstetrics & Gynecologyen
dc.identifier.urihttps://hdl.handle.net/10468/4853
dc.language.isoenen
dc.publisherWileyen
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2272/IE/Irish Centre for Fetal and Neonatal Translational Research (INFANT)/
dc.rights© 2017 The Authors. Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of the International Society of Ultrasound in Obstetrics and Gynecology. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectSmall-for-gestational ageen
dc.subjectPre-eclampsiaen
dc.subjectGrowth restrictionen
dc.subjectPlacental growth factoren
dc.titlePrediction of delivering a small for gestational age infant and adverse perinatal outcome in women with suspected pre-eclampsiaen
dc.typeArticle (peer-reviewed)en
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