dc.check.date	2024-10-06	en
dc.check.info	Access to this item is restricted for 12 months at the request of the publisher
dc.contributor.author	Nota, Minke H. C.	en
dc.contributor.author	Nicolas, Sarah	en
dc.contributor.author	O’Leary, Olivia F.	en
dc.contributor.author	Nolan, Yvonne M.	en
dc.contributor.funder	Irish Research Council	en
dc.contributor.funder	Science Foundation Ireland	en
dc.date.accessioned	2023-05-16T13:19:26Z
dc.date.available	2023-05-16T13:19:26Z
dc.date.issued	2023-04-06	en
dc.description.abstract	Adolescence is a period of biological, psychological and social changes, and the peak time for the emergence of mental health problems. During this life stage, brain plasticity including hippocampal neurogenesis is increased, which is crucial for cognitive functions and regulation of emotional responses. The hippocampus is especially susceptible to environmental and lifestyle influences, mediated by changes in physiological systems, resulting in enhanced brain plasticity but also an elevated risk for developing mental health problems. Indeed, adolescence is accompanied by increased activation of the maturing hypothalamic-pituitary-adrenal axis, sensitivity to metabolic changes due to increased nutritional needs and hormonal changes, and gut microbiota maturation. Importantly, dietary habits and levels of physical activity significantly impact these systems. In this review, the interactions between exercise and Western-style diets, which are high in fat and sugar, on adolescent stress susceptibility, metabolism and the gut microbiota are explored. We provide an overview of current knowledge on implications of these interactions for hippocampal function and adolescent mental health, and speculate on potential mechanisms which require further investigation.	en
dc.description.sponsorship	Irish Research Council (Ph.D. Scholarship GOIPG/2019/4514)	en
dc.description.status	Peer reviewed	en
dc.description.version	Accepted Version	en
dc.format.mimetype	application/pdf	en
dc.identifier.articleid	105147	en
dc.identifier.citation	Nota, M. H., Nicolas, S., O’Leary, O. F. and Nolan, Y. M. (2023) 'Outrunning a bad diet: interactions between exercise and a Western-style diet for adolescent mental health, metabolism and microbes', Neuroscience and Biobehavioral Reviews, 149, 105147 (14pp). doi: 10.1016/j.neubiorev.2023.105147	en
dc.identifier.doi	10.1016/j.neubiorev.2023.105147	en
dc.identifier.endpage	14	en
dc.identifier.issn	0149-7634	en
dc.identifier.journaltitle	Neuroscience and Biobehavioral Reviews	en
dc.identifier.startpage	1	en
dc.identifier.uri	https://hdl.handle.net/10468/14460
dc.identifier.volume	149	en
dc.language.iso	en	en
dc.publisher	Elsevier B.V.	en
dc.relation.project	info:eu-repo/grantAgreement/SFI/SFI Frontiers for the Future::Project/20/FFP-P/8758/IE/Unlocking the mechanisms underlying gut microbial regulation of adult hippocampal neurogenesis: Implications for cognitive and stress-related brain disorders./	en
dc.relation.project	info:eu-repo/grantAgreement/SFI/SFI Frontiers for the Future::Award/19/FFP/6820/IE/Mechanisms underpinning the interplay between chronic neuroinflammation and exercise on cognitive function during middle age/	en
dc.rights	© 2023, Elsevier Ltd. All rights reserved. This manuscript version is made available under the CC BY-NC-ND 4.0 license.	en
dc.rights.uri	https://creativecommons.org/licenses/by-nc-nd/4.0/	en
dc.subject	Western diet	en
dc.subject	Exercise	en
dc.subject	Adolescence	en
dc.subject	Behaviour	en
dc.subject	Mental health	en
dc.subject	Stress	en
dc.subject	Metabolism	en
dc.subject	Gut microbiota	en
dc.title	Outrunning a bad diet: Interactions between exercise and a Western-style diet for adolescent mental health, metabolism and microbes	en
dc.type	Article (peer-reviewed)	en
oaire.citation.volume	149	en

Outrunning a bad diet: Interactions between exercise and a Western-style diet for adolescent mental health, metabolism and microbes

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