Body mass index trajectories in the first 5 years and associated antenatal factors

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dc.contributor.authorMattsson, Molly
dc.contributor.authorMurray, Deirdre M.
dc.contributor.authorHawkes, Colin P.
dc.contributor.authorKiely, Mairead E.
dc.contributor.authorNí Chaoimh, Carol
dc.contributor.authorMcCarthy, Fergus P.
dc.contributor.authorBiesma, Regien
dc.contributor.authorBoland, Fiona
dc.date.accessioned2021-11-29T14:40:39Z
dc.date.available2021-11-29T14:40:39Z
dc.date.issued2021-02-19
dc.date.updated2021-11-29T14:18:33Z
dc.description.abstractBackground: The increasing prevalence of childhood obesity is an important public health issue and the development of obesity in early life and associated risk factors need to be better understood. The aim of this study was to identify distinct body mass index trajectories in the first 5 years of life and to examine their associations with factors identified in pregnancy, including metabolic parameters. Methods: BMI measurements from 2,172 children in Ireland enrolled in the BASELINE cohort study with BMI assessments at birth, 2, 6, and 12 months, and 2 and 5 years were analyzed. Growth mixture modeling was used to identify distinct BMI trajectories, and multivariate multinomial logistic regression was used to assess the association between these trajectories and antenatal factors. Results: Three distinct BMI trajectories were identified: normal (89.6%); rapid gain in the first 6 months (7.8%); and rapid BMI after 12 months (2.6%). Male sex and higher maternal age increased the likelihood of belonging to the rapid gain in the first 6 months trajectory. Raised maternal BMI at 15 weeks of pregnancy and lower cord blood IGF-2 were associated with rapid gain after 1 year. Conclusion: Sex, maternal age and BMI, and IGF-2 levels were found to be associated with BMI trajectories in early childhood departing from normal growth. Further research and extended follow-up to examine the effects of childhood growth patterns are required to understand their relationship with health outcomes.en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid622381en
dc.identifier.citationMattsson, M., Murray, D. M., Hawkes, C. P.; Kiely, M., Ní Chaoimh, C., McCarthy, F. P., Biesma, R. and Boland, F. (2021) 'Body mass index trajectories in the first 5 years and associated antenatal factors', Frontiers in Pediatrics, 9, 622381 (9pp). doi: 10.3389/fped.2021.622381en
dc.identifier.doi10.3389/fped.2021.622381en
dc.identifier.eissn2296-2360
dc.identifier.endpage9en
dc.identifier.journaltitleFrontiers in Pediatricsen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/12282
dc.identifier.volume9en
dc.language.isoenen
dc.publisherFrontiers Media S.A.en
dc.rights© 2021, Mattsson, Murray, Hawkes, Kiely, Ní Chaoimh, McCarthy, Biesma and Boland. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectGrowthen
dc.subjectChildhood obesityen
dc.subjectEpidemiologyen
dc.subjectGrowth mixture modelingen
dc.subjectIGFen
dc.titleBody mass index trajectories in the first 5 years and associated antenatal factorsen
dc.typeArticle (peer-reviewed)en
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