Dietary patterns are associated with serum metabolite patterns and their association Is influenced by gut bacteria among older German adults

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dc.contributor.authorOluwagbemigun, Kolade
dc.contributor.authorFoerster, Jana
dc.contributor.authorWatkins, Claire
dc.contributor.authorFouhy, Fiona
dc.contributor.authorStanton, Catherine
dc.contributor.authorBergmann, Manuela M.
dc.contributor.authorBoeing, Heiner
dc.contributor.authorNöthlings, Ute
dc.contributor.funderJoint Programming Initiative on Antimicrobial Resistanceen
dc.date.accessioned2019-10-14T21:54:35Z
dc.date.available2019-10-14T21:54:35Z
dc.date.issued2019-09-02
dc.description.abstractBackground: Although dietary intakes and dietary intake patterns (DPs) have been associated with single metabolites, it is unclear whether DPs are also reflected in specific metabolite patterns (MPs). Moreover, the influence of groups of gut bacteria on the relationship between DPs and MPs is underexplored. Objectives: We aimed to investigate the association of DPs and serum MPs and also the modifying effect of the gut bacteria compositional patterns (BCPs). Methods: This is a cross-sectional investigation among 225 individuals (median age: 63 y; 53% women) from the European Prospective Investigation into Cancer and Nutrition study. Dietary intakes were assessed by three 24-h dietary recalls, gut bacteria composition was quantified by 16S rRNA gene sequencing, and the serum metabolome was profiled by an untargeted approach. We identified DPs and BCPs by the treelet transform analysis. We modeled associations between DPs and 8 previously published MPs and the modifying effect of BCPs by fitting generalized linear models using DataSHIELD R. Results: We identified 5 DPs and 7 BCPs. The “bread, margarine, and processed meat” and “fruiting vegetables and vegetable oils” DPs were positively associated with the “amino acids” (β = 0.35; 95% CI: 0.02, 0.69; P = 0.03) and “fatty acids” MPs (β = 0.45; 95% CI: 0.16, 0.74; P = 0.01), respectively. The “tea and miscellaneous” was inversely associated with the “amino acids” (β = −0.28; 95% CI: −0.52, −0.05; P = 0.02) and “amino acid derivatives” MPs (β = −0.21; 95% CI: −0.39, −0.02; P = 0.03). One BCP negatively modified the association between the “bread, margarine, and processed meat” DP and the “amino acids” MP (P-interaction = 0.01). Conclusions: In older German adults, DPs are reflected in MPs, and the gut bacteria attenuate 1 DP–MP association. These MPs should be explored as biomarkers of these jointly consumed foods while taking into account a potentially modifying role of the gut bacteria.en
dc.description.sponsorshipEuropean Joint Programming Initiative (“A Healthy Diet for a Healthy Life” Metabolic HEALTH through Nutrition, Microbiota and Tryptophan bioMARKers (HEALTHMARK) project)en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleidnxz194en
dc.identifier.citationOluwagbemigun, K., Foerster, J., Watkins, C., Fouhy, F., Stanton, C., Bergmann, M. M., Boeing, H. and Nöthlings, U. (2019) 'Dietary Patterns Are Associated with Serum Metabolite Patterns and Their Association Is Influenced by Gut Bacteria among Older German Adults', Journal of Nutrition, nxz194 (10pp.). DOI: 10.1093/jn/nxz194en
dc.identifier.doi10.1093/jn/nxz194en
dc.identifier.eissn1541-6100
dc.identifier.endpage10en
dc.identifier.issn0022-3166
dc.identifier.journaltitleJournal of Nutritionen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/8756
dc.language.isoenen
dc.publisherOxford University Pressen
dc.relation.urihttps://academic.oup.com/jn/article/doi/10.1093/jn/nxz194/5558305/#148802936
dc.rights©American Society for Nutrition 2019. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com Supplementary dataen
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/en
dc.subjectDietary intake patternsen
dc.subjectGut bacteria compositional patternsen
dc.subjectSerum metabolite patternsen
dc.subjectTreelet transform analysisen
dc.subjectDataSHIELDen
dc.subjectAmino acidsen
dc.subjectDieten
dc.subjectAdulten
dc.subjectBreaden
dc.subjectFooden
dc.subjectGenesen
dc.subjectMargarineen
dc.subjectMucopolysaccharidosesen
dc.subjectOilsen
dc.subjectRNAen
dc.subjectRibosomalen
dc.subject16sen
dc.subjectMassively-parallel genome sequencingen
dc.titleDietary patterns are associated with serum metabolite patterns and their association Is influenced by gut bacteria among older German adultsen
dc.typeArticle (peer-reviewed)en
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