Chitosan gel film bandages: correlating structure, composition, and antimicrobial properties

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dc.contributor.authorAnaya, P.
dc.contributor.authorCárdenas, G.
dc.contributor.authorLavayen, Vladimir
dc.contributor.authorGarcía, A.
dc.contributor.authorO'Dwyer, Colm
dc.contributor.funderScience Foundation Irelanden
dc.date.accessioned2016-06-29T11:38:47Z
dc.date.available2016-06-29T11:38:47Z
dc.date.issued2012-10-16
dc.date.updated2012-11-29T17:23:43Z
dc.description.abstractChitosan gel films were successfully obtained by evaporation cast from chitosan solutions in aqueous acidic solutions of organic acids (lactic and acetic acid) as gel film bandages, with a range of additives that directly influence film morphology and porosity. We show that the structure and composition of a wide range of 128 thin gel films, is correlated to the antimicrobial properties, their biocompatibility and resistance to biodegradation. Infrared spectroscopy and solid-state 13C nuclear magnetic resonance spectroscopy was used to correlate film molecular structure and composition to good antimicrobial properties against 10 of the most prevalent Gram positive and Gram negative bacteria. Chitosan gel films reduce the number of colonies after 24 h of incubation by factors of ∼105–107 CFU/mL, compared with controls. For each of these films, the structure and preparation condition has a direct relationship to antimicrobial activity and effectiveness. These gel film bandages also show excellent stability against biodegradation with lysozyme under physiological conditions (5% weight loss over a period of 1 month, 2% in the first week), allowing use during the entire healing process. These chitosan thin films and subsequent derivatives hold potential as low-cost, dissolvable bandages, or second skin, with antimicrobial properties that prohibit the most relevant intrahospital bacteria that infest burn injuries.en
dc.description.sponsorshipInnova Bio-Bio, Chile (Grant 03-B1-212-L1); Conselho Nacional de Desenvolvimento Científico e Tecnológico, Brazil (CNPq, (400297/2010-8)); Fondo Nacional de Desarrollo Científico y Tecnológico, Chile (FONDECyT (1090683, 1090282)); Irish Government (INSPIRE Program, Program for Research in Third Level Institutions, Cycle 4, National Development Plan 2007-2013); Science Foundation Ireland (SFI contract no. 07/SK/B1232a.)en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationAnaya, P., Cárdenas, G., Lavayen, V., García, A. & O'Dwyer, C. (2013) ‘Chitosan gel film bandages: correlating structure, composition, and antimicrobial properties’, Journal of Applied Polymer Science, 128(6), pp. 3939-3948. http://dx.doi.org/10.1002/app.38621en
dc.identifier.doi10.1002/app.38621
dc.identifier.endpage3948en
dc.identifier.issn0021-8995
dc.identifier.issued6en
dc.identifier.journaltitleJournal of Applied Polymer Scienceen
dc.identifier.startpage3939en
dc.identifier.urihttps://hdl.handle.net/10468/2810
dc.identifier.volume128en
dc.language.isoenen
dc.publisherWileyen
dc.rights© 2012 Wiley Periodicals, Inc. This is the peer reviewed version of the following article: Anaya, P eta al., ‘Chitosan gel film bandages: correlating structure, composition, and antimicrobial properties’, Journal of Applied Polymer Science, 128, pp. 3939-3948 which has been published in final form at http://dx.doi.org/10.1002/app.38621. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.en
dc.subjectBiodegradableen
dc.subjectBiomedical applicationsen
dc.subjectBiopolymers and renewable polymersen
dc.subjectGelsen
dc.subjectBiocompatibilityen
dc.titleChitosan gel film bandages: correlating structure, composition, and antimicrobial propertiesen
dc.typeArticle (peer-reviewed)en
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