Maternal distress in late pregnancy alters obstetric outcomes and the expression of genes important for placental glucocorticoid signalling

Togher, Katie L.; Treacy, Eimear; O'Keeffe, Gerard W.; Kenny, Louise C.

Access to this article is restricted until 12 months after publication by request of the publisher.. Restriction lift date: 2018-05-08

Maternal distress in late pregnancy alters obstetric outcomes and the expression of genes important for placental glucocorticoid signalling

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dc.check.date	2018-05-08
dc.check.info	Access to this article is restricted until 12 months after publication by request of the publisher.	en
dc.contributor.author	Togher, Katie L.
dc.contributor.author	Treacy, Eimear
dc.contributor.author	O'Keeffe, Gerard W.
dc.contributor.author	Kenny, Louise C.
dc.contributor.funder	Science Foundation Ireland	en
dc.contributor.funder	University College Cork	en
dc.contributor.funder	College of Medicine and Health, University College Cork
dc.date.accessioned	2018-01-30T12:49:47Z
dc.date.available	2018-01-30T12:49:47Z
dc.date.issued	2017-05-08
dc.date.updated	2018-01-30T09:39:39Z
dc.description.abstract	The experience of maternal distress in pregnancy is often linked with poorer obstetric outcomes for women as well as adverse outcomes for offspring. Alterations in placental glucocorticoid signalling and subsequent increased fetal exposure to cortisol have been suggested to underlie this relationship. In the current study, 121 pregnant women completed the Perceived Stress Scale, State Trait Anxiety Inventory and Edinburgh Postnatal Depression Scale in the third trimester of pregnancy. Placental samples were collected after delivery. Maternal history of psychiatric illness and miscarriage were significant predictors of poorer mental health in pregnancy. Higher anxiety was associated with an increase in women delivering via elective Caesarean Section, and an increase in bottle-feeding. Birth temperature was mildly reduced among infants of women with high levels of depressive symptomology. Babies of mothers who scored high in all stress (cumulative distress) measures had reduced 5-min Apgar scores. High cumulative distress reduced the expression of placental HSD11B2 mRNA and increased the expression of placental NR3C1 mRNA. These data support a role for prenatal distress as a risk factor for altered obstetric outcomes. The alterations in placental gene expression support a role for altered placental glucocorticoid signalling in the relationship between maternal prenatal distress and adverse outcomes.	en
dc.description.sponsorship	College of Medicine and Health, University College Cork (Translational Research Access Program (TRAP) Award)	en
dc.description.status	Peer reviewed	en
dc.description.version	Accepted Version	en
dc.format.mimetype	application/pdf	en
dc.identifier.citation	Togher, K. L., Treacy, E., O’Keeffe, G. W. and Kenny, L. C. (2017) ‘Maternal distress in late pregnancy alters obstetric outcomes and the expression of genes important for placental glucocorticoid signalling’, Psychiatry Research, 255, pp. 17-26. doi:10.1016/j.psychres.2017.05.013	en
dc.identifier.doi	10.1016/j.psychres.2017.05.013
dc.identifier.endpage	26	en
dc.identifier.issn	0165-1781
dc.identifier.issn	1872-7123
dc.identifier.journaltitle	Psychiatry Research	en
dc.identifier.startpage	17	en
dc.identifier.uri	https://hdl.handle.net/10468/5350
dc.identifier.volume	255	en
dc.language.iso	en	en
dc.publisher	Elsevier B.V.	en
dc.relation.project	info:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2272/IE/Irish Centre for Fetal and Neonatal Translational Research (INFANT)/	en
dc.relation.project	info:eu-repo/grantAgreement/SFI/SFI Research Frontiers Programme (RFP)/10/RFP/NES2786/IE/Defining the potential of the transmembrane GITR receptor as a novel therapeutic for PNS neuropathies./	en
dc.rights	© 2017 Elsevier B.V. All rights reserved. This manuscript version is made available under the CC-BY-NC-ND 4.0 license.	en
dc.rights.uri	https://creativecommons.org/licenses/by-nc-nd/4.0/	en
dc.subject	Anxiety	en
dc.subject	Depression	en
dc.subject	Maternal	en
dc.subject	Obstetric	en
dc.subject	Placenta	en
dc.subject	Pregnancy	en
dc.subject	Prenatal	en
dc.subject	Stress	en
dc.title	Maternal distress in late pregnancy alters obstetric outcomes and the expression of genes important for placental glucocorticoid signalling	en
dc.type	Article (peer-reviewed)	en