Treating generational stress: effect of paternal stress on development of memory and extinction in offspring is reversed by probiotic treatment

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dc.contributor.authorCallaghan, Bridget L.
dc.contributor.authorCowan, Caitlin S. M.
dc.contributor.authorRichardson, Rick
dc.contributor.funderAustralian Research Councilen
dc.contributor.funderNational Health and Medical Research Councilen
dc.contributor.funderPetre Foundationen
dc.date.accessioned2019-02-06T15:10:05Z
dc.date.available2019-02-06T15:10:05Z
dc.date.issued2016-09
dc.date.updated2019-02-05T16:57:11Z
dc.description.abstractEarly-life adversity is a potent risk factor for mental-health disorders in exposed individuals, and effects of adversity are exhibited across generations. Such adversities are also associated with poor gastrointestinal outcomes. In addition, emerging evidence suggests that microbiota-gut-brain interactions may mediate the effects of early-life stress on psychological dysfunction. In the present study, we administered an early-life stressor (i.e., maternal separation) to infant male rats, and we investigated the effects of this stressor on conditioned aversive reactions in the rats' subsequent infant male offspring. We demonstrated, for the first time, longer-lasting aversive associations and greater relapse after extinction in the offspring (F1 generation) of rats exposed to maternal separation (F0 generation), compared with the offspring of rats not exposed to maternal separation. These generational effects were reversed by probiotic supplementation, which was effective as both an active treatment when administered to infant F1 rats and as a prophylactic when administered to F0 fathers before conception (i.e., in fathers' infancy). These findings have high clinical relevance in the identification of early-emerging putative risk phenotypes across generations and of potential therapies to ameliorate such generational effects.en
dc.description.sponsorshipNational Health and Medical Research Council Project grant ((APP1031688); Early Career Fellowship); Australian Postgraduate Award; Petre Foundation (scholarship);en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationCallaghan, B. L., Cowan, C. S. M. and Richardson, R. (2016) 'Treating Generational Stress:Effect of Paternal Stress on Development of Memory and Extinction in Offspring Is Reversed by Probiotic Treatment', Psychological Science, 27(9), pp. 1171-1180. doi: 10.1177/0956797616653103en
dc.identifier.doi10.1177/0956797616653103
dc.identifier.endpage1180en
dc.identifier.issn1467-9280
dc.identifier.issued9en
dc.identifier.journaltitlePsychological Scienceen
dc.identifier.startpage1171en
dc.identifier.urihttps://hdl.handle.net/10468/7456
dc.identifier.volume27en
dc.language.isoenen
dc.publisherSageen
dc.relation.projectinfo:eu-repo/grantAgreement/ARC/Discovery Projects/DP0985554/AU/Developmental analysis of extinction of learned fear in rats/en
dc.relation.projectinfo:eu-repo/grantAgreement/ARC/Discovery Projects/DP120104925/AU/Effects of early life trauma on fear memory and fear extinction in rats/en
dc.relation.urihttps://journals.sagepub.com/doi/abs/10.1177/0956797616653103
dc.rights© 2016 Sage Publications. Reprinted by permission of SAGE Publications.en
dc.subjectMaternal separationen
dc.subjectExtinctionen
dc.subjectPavlovian conditioningen
dc.subjectInfantile amnesiaen
dc.subjectInheritanceen
dc.subjectGenerational effectsen
dc.subjectProbioticen
dc.titleTreating generational stress: effect of paternal stress on development of memory and extinction in offspring is reversed by probiotic treatmenten
dc.typeArticle (peer-reviewed)en
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