Gut microbial metabolite-mediated regulation of the intestinal barrier in the pathogenesis of inflammatory bowel disease

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dc.contributor.authorIyer, Namrataen
dc.contributor.authorCorr, Sinéad C.en
dc.contributor.funderScience Foundation Irelanden
dc.contributor.funderHorizon 2020en
dc.date.accessioned2023-06-01T14:38:30Z
dc.date.available2023-06-01T14:38:30Z
dc.date.issued2021-11-26T00:00:00Zen
dc.description.abstractInflammatory bowel disease (IBD) is a chronic inflammatory disease. The disease has a multifactorial aetiology, involving genetic, microbial as well as environmental factors. The disease pathogenesis operates at the host-microbe interface in the gut. The intestinal epithelium plays a central role in IBD disease pathogenesis. Apart from being a physical barrier, the epithelium acts as a node that integrates environmental, dietary, and microbial cues to calibrate host immune response and maintain homeostasis in the gut. IBD patients display microbial dysbiosis in the gut, combined with an increased barrier permeability that contributes to disease pathogenesis. Metabolites produced by microbes in the gut are dynamic indicators of diet, host, and microbial interplay in the gut. Microbial metabolites are actively absorbed or diffused across the intestinal lining to affect the host response in the intestine as well as at systemic sites via the engagement of cognate receptors. In this review, we summarize insights from metabolomics studies, uncovering the dynamic changes in gut metabolite profiles in IBD and their importance as potential diagnostic and prognostic biomarkers of disease. We focus on gut microbial metabolites as key regulators of the intestinal barrier and their role in the pathogenesis of IBD.en
dc.description.sponsorshipScience Foundation Ireland (9/FFP/6499)en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid4259en
dc.identifier.citationIyer, N. and Corr, S. C. (2021) 'Gut microbial metabolite-mediated regulation of the intestinal barrier in the pathogenesis of inflammatory bowel disease', Nutrients, 13(12), 4259 (26pp). doi: 10.3390/nu13124259en
dc.identifier.doi10.3390/nu13124259en
dc.identifier.eissn2072-6643en
dc.identifier.endpage26en
dc.identifier.issued12en
dc.identifier.journaltitleNutrientsen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/14540
dc.identifier.volume13en
dc.language.isoenen
dc.publisherMDPIen
dc.relation.projectinfo:eu-repo/grantAgreement/EC/H2020::MSCA-COFUND-FP/754535/EU/APC Postdoctoral EXcellence Programme/APEXen
dc.rights© 2021, the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectGut barrieren
dc.subjectInflammatory bowel diseaseen
dc.subjectIntestinal epitheliumen
dc.subjectMetabolitesen
dc.subjectMetabolomeen
dc.subjectMetabolomicsen
dc.subjectMicrobiomeen
dc.titleGut microbial metabolite-mediated regulation of the intestinal barrier in the pathogenesis of inflammatory bowel diseaseen
dc.typeArticle (peer-reviewed)en
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