In-hospital adverse drug reactions in hospitalised older adults - a systematic review

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dc.contributor.authorJennings, Emma L. M.
dc.contributor.authorMurphy, Kevin D.
dc.contributor.authorGallagher, Paul F.
dc.contributor.authorO'Mahony, Denis
dc.contributor.funderHorizon 2020en
dc.date.accessioned2018-12-14T15:48:01Z
dc.date.available2018-12-14T15:48:01Z
dc.date.issued2018-10
dc.date.updated2018-12-13T08:06:25Z
dc.description.abstractIntroduction: Studies indicate 1 in 4 older people experience hospital-related adverse drug reactions [ADRs]. This systematic-review aims to evaluate in-hospital ADRs in hospitalised older-adults in terms of incidence, prevalence, most commonly involved drug classes, severity, and consequences. Methods: Using PRISMA methodology [PROSPERO CRD42018079095], we searched PubMed, Embase, Ebsco-CINAHL, Cochrane Library, library hosted sources, Google scholar, and ‘grey’ literature, using terms; aged, ADRs, hospitalized, multi-morbid, polypharmacy and hospital-acquired. References of editorials and systematic reviews were hand searched. Studies of all languages and dates until 15/01/2018 were included. All studies reporting ADRs outcomes, ≥65 years, hospitalised at time of ADR occurrence were included. Two researchers screened all papers for inclusion, risk of bias and data extraction. Results: Initial search yielded 1721 abstracts, 200 underwent full text screening. 60 were potentially suitable for inclusion; 48 papers reported combined ages, 12 papers reported directly on ADRs in our age cohort [2 papers reported the same data]. 11 studies [4424 patients] were analysed; 24% [1064] experienced ADRs. 7 reported severity (n = 707); 31% [220] being severe. 5 reported on post-ADR outcomes i.e. length of stay [n = 3], death [n = 1] and functional decline [n = 1]. Frequency of culprit drug-groups were described in 6 [672 ADRs]; 43% [291] cardiovascular system, 17% [114] central nervous system, 16% [112] clotting pathways, 13% [90] anti-microbials. Conclusions: One in four over 65 years experience an ADR during hospitalisation, one third being severe, and almost half cardiovascular system drugs. Clinical outcomes associated with ADRs are generally poorly described in the literature.en
dc.description.abstractPoster presentationen
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationJennings E., Murphy K., Gallagher P. and O'Mahony D (2018) In-hospital adverse drug reactions in hospitalised older adults - a systematic review, 14th International Congress of the EuGMS Berlin, 10-12 October, in Abstracts of the 14th International Congress of the European Geriatric Medicine Society, European Geriatric Medicine, 9 (supplement 1), p. s62. doi: 10.1007/s41999-018-0097-4en
dc.identifier.doi10.1007/s41999-018-0097-4
dc.identifier.issn1878-7649
dc.identifier.issn1878-7657
dc.identifier.issuedSupplement 1en
dc.identifier.journaltitleEuropean Geriatric Medicineen
dc.identifier.startpageS62en
dc.identifier.urihttps://hdl.handle.net/10468/7224
dc.identifier.volume9en
dc.language.isoenen
dc.publisherSpringeren
dc.relation.ispartof14th International Congress of the EuGMS
dc.relation.urihttps://doi.org/10.1007/s41999-018-0097-4
dc.rights© European Geriatric Medicine Society 2018en
dc.subjectGeriatric medicineen
dc.subjectAdverse effects of medicationen
dc.subjectADRen
dc.subjectHospital acquireden
dc.titleIn-hospital adverse drug reactions in hospitalised older adults - a systematic reviewen
dc.typeConference itemen
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