Mode of prostate cancer detection is associated with the psychological wellbeing of survivors: results from the PiCTure study

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dc.contributor.authorDrummond, Frances J.
dc.contributor.authorO'Leary, Eamonn
dc.contributor.authorGavin, Anna T.
dc.contributor.authorKinnear, Heather
dc.contributor.authorLinda, Sharp
dc.contributor.funderHealth Research Boarden
dc.contributor.funderProstate Cancer UKen
dc.contributor.funderNational Cancer Control Programmeen
dc.contributor.funderPublic Health Agencyen
dc.date.accessioned2019-10-26T07:13:57Z
dc.date.available2019-10-26T07:13:57Z
dc.date.issued2015-11-23
dc.description.abstractPurpose: Many men with prostate cancer are asymptomatic, diagnosed following prostate specific antigen (PSA) testing. We investigate whether mode of detection, i.e. ‘PSA detected’ or ‘clinically detected’, was associated with psychological wellbeing among prostate cancer survivors. Methods: A cross-sectional postal questionnaire was administered in 2012 to 6559 prostate cancer (ICD10 C61) survivors up to 18 years post-diagnosis, identified through population-based cancer registries in Ireland. Psychological wellbeing was assessed using the Depression Anxiety Stress Scale-21. Logistic regression was used to investigate associations between mode of detection and depression, anxiety and stress, adjusting for socio-demographic and clinical confounders. Results: The response rate was 54 % (3348/6262). Fifty-nine percent of survivors were diagnosed with asymptomatic PSA-tested disease. Prevalence of depression (13.8 vs 20.7 %; p < 0.001), anxiety (13.6 vs 20.9 %; p < 0.001) and stress (8.7 vs 13.8 %; p < 0.001) were significantly lower among survivors diagnosed with PSA-detected, than clinically detected disease. After adjusting for clinical and socio-demographic factors, survivors with clinically detected disease had significantly higher risk of depression (odds ratio (OR) = 1.46 95 % CI 1.18, 1.80; p = 0.001), anxiety (OR = 1.36 95 % CI 1.09, 1.68; p = 0.006) and stress (OR = 1.43 95 % CI 1.11, 1.85; p = 0.006) than survivors with PSA-detected disease. Conclusions: These findings contribute to the ongoing debate on benefits and risks of PSA testing and may be considered by policy makers formulating population-based prostate cancer screening policies. The relatively high prevalence of negative psychological states among survivors means that a ‘risk-adapted approach’ should be implemented to screen survivors most at risk of psychological morbidity for psychological health, and mode of detection could be considered as a risk stratum.en
dc.description.sponsorshipHealth Research Board (HRA_HSR/2010/17); Prostate Cancer UK (NI09-03);en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationDrummond, F. J., O’Leary, E., Gavin, A., Kinnear, H. and Sharp, L. (2016), 'Mode of prostate cancer detection is associated with the psychological wellbeing of survivors: results from the PiCTure study', Supportive Care in Cancer, 24(5), pp. 2297-2307. DOI: 10.1007/s00520-015-3033-xen
dc.identifier.doi10.1007/s00520-015-3033-xen
dc.identifier.eissn1433-7339
dc.identifier.endpage2307en
dc.identifier.issn0941-4355
dc.identifier.issued5en
dc.identifier.journaltitleSupportive Care in Canceren
dc.identifier.startpage2297en
dc.identifier.urihttps://hdl.handle.net/10468/8881
dc.identifier.volume24en
dc.language.isoenen
dc.publisherSpring Berlin Heidelbergen
dc.relation.urihttps://link.springer.com/article/10.1007%2Fs00520-015-3033-x
dc.rights©The Author(s) 2015. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits use, duplication, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectProstate canceren
dc.subjectDepressionen
dc.subjectAnxietyen
dc.subjectStressen
dc.subjectProstate specific antigenen
dc.subjectPSAen
dc.subjectScreeningen
dc.titleMode of prostate cancer detection is associated with the psychological wellbeing of survivors: results from the PiCTure studyen
dc.typeArticle (peer-reviewed)en
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