Clinical characteristics of patients with refractory non-epileptic seizures
| dc.contributor.author | Fullam, Sarah | en |
| dc.contributor.author | Costello, Daniel J. | en |
| dc.date.accessioned | 2024-06-17T11:58:32Z | |
| dc.date.available | 2024-06-17T11:58:32Z | |
| dc.date.issued | 2024-04-19 | en |
| dc.description.abstract | Objectives: This incidence of non-epileptic seizures (NES) is estimated at 1–35 per 100,000 population. While many patients achieve remission, a significant fraction of patients have a poor prognosis despite optimal interventions. This study reports on the characteristics of patients with refractory NES diagnosed and treated at a comprehensive epilepsy centre. Methods: A retrospective review of admissions to the Epilepsy Monitoring Unit identified patients diagnosed with NES over a 6-year period. Patients with refractory NES were identified through review of medical files. A diagnosis of refractory NES was assigned when patients experienced ongoing NES at least 1 year after diagnostic video-EEG monitoring. Data pertaining to predisposing, precipitating and perpetuating factors was collected on all patients and a comparative analysis was conducted between refractory and non-refractory cases. Results: 66 patients with NES were identified, 35% were deemed refractory. There was no significant difference amongst predisposing factors between the groups. Psychosocial adversity and a clear precipitant proximate to the onset of NES were significantly more common in the refractory cohort. Unemployment at time of diagnosis was a significant perpetuating factor associated with poor outcome. Conclusion: This study provides insight into the features associated with refractory NES and may serve to improve prognostication and management in this disabling condition. | en |
| dc.description.status | Peer reviewed | en |
| dc.description.version | Published Version | en |
| dc.format.mimetype | application/pdf | en |
| dc.identifier.articleid | 109783 | en |
| dc.identifier.citation | Fullam, S. and Costello, D.J. (2024) ‘Clinical characteristics of patients with refractory non-epileptic seizures’, Epilepsy & Behavior, 155, 109783. Available at: https://doi.org/10.1016/j.yebeh.2024.109783. | en |
| dc.identifier.doi | https://doi.org/10.1016/j.yebeh.2024.109783. | en |
| dc.identifier.endpage | 5 | en |
| dc.identifier.issn | 1525-5050 | en |
| dc.identifier.journaltitle | Epilepsy & Behavior, | en |
| dc.identifier.startpage | 1 | en |
| dc.identifier.uri | https://hdl.handle.net/10468/16012 | |
| dc.identifier.volume | 155 | en |
| dc.language.iso | en | en |
| dc.publisher | Elsevier | en |
| dc.rights | © 2024 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). | en |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | en |
| dc.subject | Non-epileptic seizures | en |
| dc.subject | Refractory | en |
| dc.subject | Clinical features | en |
| dc.title | Clinical characteristics of patients with refractory non-epileptic seizures | en |
| dc.type | Article (peer-reviewed) | en |
| oaire.citation.volume | 155 | en |
