Next-generation probiotics: the spectrum from probiotics to live biotherapeutics

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dc.contributor.authorO'Toole, Paul W.
dc.contributor.authorMarchesi, Julian R.
dc.contributor.authorHill, Colin
dc.contributor.funderScience Foundation Irelanden
dc.date.accessioned2019-09-12T11:59:20Z
dc.date.available2019-09-12T11:59:20Z
dc.date.issued2017-04-25
dc.date.updated2019-09-12T11:51:05Z
dc.description.abstractThe leading probiotics currently available to consumers are generally drawn from a narrow range of organisms. Knowledge of the gut microbiota and its constituent actors is changing this paradigm, particularly given the phylogenetic range and relatively unknown characteristics of the organisms under investigation as novel therapeutics. For this reason, and because their development is likely to be more amenable to a pharmaceutical than a food delivery route, these organisms are often operationally referred to as next-generation probiotics, a concept that overlaps with the emerging concept of live biotherapeutic products. The latter is a class of organisms developed exclusively for pharmaceutical application. In this Perspective, we discuss what lessons have been learned from working with traditional probiotics, explore the kinds of organisms that are likely to be used as novel microbial therapeutics, discuss the regulatory framework required, and propose how scientists may meet this challenge.en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid17057en
dc.identifier.citationO'Toole, P. W., Marchesi, J. R. and Hill, C. (2017) 'Next-generation probiotics: the spectrum from probiotics to live biotherapeutics', Nature Microbiology, 2, 17057 (6pp). doi: 10.1038/nmicrobiol.2017.57en
dc.identifier.doi10.1038/nmicrobiol.2017.57en
dc.identifier.eissn2058-5276
dc.identifier.endpage6en
dc.identifier.journaltitleNature Microbiologyen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/8523
dc.identifier.volume2en
dc.language.isoenen
dc.publisherSpringer Nature Limiteden
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/en
dc.rights© 2017, Macmillan Publishers Limited, part of Springer Nature. All rights reserved.en
dc.subjectProbioticen
dc.subjectGut microbiotaen
dc.subjectPharmaceutical applicationen
dc.subjectNovel microbial therapeuticsen
dc.titleNext-generation probiotics: the spectrum from probiotics to live biotherapeuticsen
dc.typeArticle (peer-reviewed)en
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