Predicted 10-year risk of cardiovascular mortality in the 40 to 69 year old general population without cardiovascular diseases in Germany

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dc.contributor.authorDiederichs, Claudia
dc.contributor.authorNeuhauser, Hannelore
dc.contributor.authorRücker, Viktoria
dc.contributor.authorBusch, Markus A.
dc.contributor.authorKeil, Ulrich
dc.contributor.authorFitzgerald, Anthony P.
dc.contributor.authorHeuschmann, Peter U.
dc.contributor.funderDeutsches Zentrum für Herz-Kreislaufforschungen
dc.contributor.funderBundesministerium für Bildung und Forschungen
dc.contributor.funderBundesministerium für Gesundheiten
dc.date.accessioned2018-02-20T12:45:13Z
dc.date.available2018-02-20T12:45:13Z
dc.date.issued2018-01-03
dc.description.abstractAims To estimate the 10-year risk of fatal cardiovascular disease (CVD) in the 40 to 69 year old general population in Germany stratified by sex and to analyze differences between socio-economic status (SES), region and community size in individuals without CVD. The analysis is based on the newly recalibrated SCORE Deutschland risk charts and considered other comorbidities for the classification of the high CVD risk group according to the guidelines of the European Society of Cardiology. Methods and results In 3,498 participants (40–69 years) from the German Health Examination Survey for Adults 2008–2011 (DEGS1) without a history of CVD (myocardial infarction, coronary heart disease, heart failure, stroke) we estimated the proportion with a low (SCORE <1%), moderate (SCORE 1-<5%) and high 10-year CVD mortality risk (SCORE ≥5% or diabetes, renal insufficiency, SBP/DPB ≥180/110 mmHg or cholesterol >8 mmol/l). The prevalence of low, moderate and high risk was 42.8%, 38.5% and 18.8% in men and 73.7%, 18.1% and 8.2% in women. The prevalence of high risk was significantly lower in women with a high compared to a low SES (3.3% vs. 11.2%) and in communities with ≥100.000 inhabitants compared to <20.000 inhabitants (5.4% vs.10.9%). There were no significant associations between predicted CVD mortality risk and SES or community size in men and regions in men and women. Among the high risk group, 58.2% of men and 9.8% of women had SCORE ≥5%, leaving the majority of women (60.1%) classified as high risks due to diabetes and SCORE <5%. Conclusion Our results suggest the persistence of socioeconomic disparities in predicted cardiovascular mortality in women and support the need of large-scale prevention efforts beyond individual lifestyle modification or treatment. Furthermore, the importance of additional comorbidities for the high risk group classification is highlighted.en
dc.description.sponsorshipDZHK (German Centre for Cardiovascular Research) grant number MDC2012Z1en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleide0190441
dc.identifier.citationDiederichs C, Neuhauser H, Rücker V, Busch MA, Keil U, Fitzgerald AP, et al. (2018) Predicted 10-year risk of cardiovascular mortality in the 40 to 69 year old general population without cardiovascular diseases in Germany. PLoS ONE 13(1): e0190441. https://doi.org/10.1371/journal.pone.0190441en
dc.identifier.doi10.1371/journal.pone.0190441
dc.identifier.issn1932-6203
dc.identifier.issued1en
dc.identifier.journaltitlePLoS ONEen
dc.identifier.urihttps://hdl.handle.net/10468/5488
dc.identifier.volume13en
dc.language.isoenen
dc.publisherPublic Library of Scienceen
dc.rights© 2018 Diederichs et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectCardiovascular mortalityen
dc.subjectCardiovascular diseasesen
dc.subjectGermanyen
dc.subject40 to 69 yearsen
dc.titlePredicted 10-year risk of cardiovascular mortality in the 40 to 69 year old general population without cardiovascular diseases in Germanyen
dc.typeArticle (peer-reviewed)en
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