Integration of a capacitive pressure sensing system into the outer catheter wall for coronary artery FFR measurements

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dc.contributor.authorStam, Frank
dc.contributor.authorKuisma, Heikki
dc.contributor.authorGao, Feng
dc.contributor.authorSaarilahti, Jaakko
dc.contributor.authorGomes Martins, David
dc.contributor.authorKärkkäinen, Anu
dc.contributor.authorMarrinan, Brendan
dc.contributor.authorPintal, Sebastian
dc.contributor.editorvan den Driesche, Sander
dc.contributor.editorGiouroudi, Ioanna
dc.contributor.editorDelgado-Restituto, Manuel
dc.contributor.funderSeventh Framework Programmeen
dc.contributor.funderEnterprise Irelanden
dc.date.accessioned2018-04-18T15:19:30Z
dc.date.available2018-04-18T15:19:30Z
dc.date.issued2017-05
dc.date.updated2018-04-18T14:45:01Z
dc.description.abstractThe deadliest disease in the world is coronary artery disease (CAD), which is related to a narrowing (stenosis) of blood vessels due to fatty deposits, plaque, on the arterial walls. The level of stenosis in the coronary arteries can be assessed by Fractional Flow Reserve (FFR) measurements. This involves determining the ratio between the maximum achievable blood flow in a diseased coronary artery and the theoretical maximum flow in a normal coronary artery. The blood flow is represented by a pressure drop, thus a pressure wire or pressure sensor integrated in a catheter can be used to calculate the ratio between the coronary pressure distal to the stenosis and the normal coronary pressure. A 2 Fr (0.67mm) outer diameter catheter was used, which required a high level of microelectronics miniaturisation to fit a pressure sensing system into the outer wall. The catheter has an eccentric guidewire lumen with a diameter of 0.43mm, which implies that the thickest catheter wall section provides less than 210 microns height for flex assembly integration consisting of two dies, a capacitive MEMS pressure sensor and an ASIC. In order to achieve this a very thin circuit flex was used, and the two chips were thinned down to 75 microns and flip chip mounted face down on the flex. Many challenges were involved in obtaining a flex layout that could wrap into a small tube without getting the dies damaged, while still maintaining enough flexibility for the catheter to navigate the arterial system.en
dc.description.sponsorshipEnterprise Ireland (International Research Fund contract n° IR 2015 0029)en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationStam, F., Kuisma, H., Gao, F., Saarilahti, J., Martins, D. G., Kärkkäinen, A., Marrinan, B. and Pintal, S. (2017) 'Integration of a capacitive pressure sensing system into the outer catheter wall for coronary artery FFR measurements', Proceedings SPIE 10247, Bio-MEMS and Medical Microdevices III, 1024703 (10pp), doi: 10.1117/12.2263779en
dc.identifier.doi10.1117/12.2263779
dc.identifier.endpage1024703-10en
dc.identifier.journaltitleBio-MEMS and Medical Microdevices III, SPIE Proceedingsen
dc.identifier.startpage1024703-1en
dc.identifier.urihttps://hdl.handle.net/10468/5822
dc.identifier.volume10247en
dc.language.isoenen
dc.publisherSociety of Photo-Optical Instrumentation Engineers (SPIE)en
dc.relation.ispartofSPIE Microtechnologies, Bio-MEMS and Medical Microdevices III
dc.relation.projectinfo:eu-repo/grantAgreement/EC/FP7::SP1::SP1-JTI/621278/EU/Intelligent Catheters in Advanced Systems for Interventions/INCITEen
dc.relation.urihttps://www.spiedigitallibrary.org/conference-proceedings-of-spie/10247
dc.rights© 2017 SPIE .Copyright 2017 Society of Photo Optical Instrumentation Engineers (SPIE). One print or electronic copy may be made for personal use only. Systematic electronic or print reproduction and distribution, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited.en
dc.subjectCapacitive pressure sensingen
dc.subjectFFR measurementen
dc.subjectcatheter wallen
dc.subjectMemsen
dc.subjectAsicen
dc.subjectFractional Flow Reserve (FFR),en
dc.subjectCatheter integrationen
dc.subjectFlexible circuiten
dc.subjectCapacitive pressure sensoren
dc.subjectChip bumping & coiningen
dc.subjectDie thinningen
dc.subjectFlip chip interconnecten
dc.subjectSolder laser jettingen
dc.titleIntegration of a capacitive pressure sensing system into the outer catheter wall for coronary artery FFR measurementsen
dc.typeConference itemen
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