The microbiome and the pathophysiology of asthma

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dc.contributor.authorSullivan, Ashley
dc.contributor.authorHunt, Eoin
dc.contributor.authorMacSharry, John
dc.contributor.authorMurphy, Desmond M.
dc.contributor.funderWilton Respiratory Research Fund
dc.contributor.funderAPC Microbiome Institute, College of Medicine and Health, University College Cork
dc.date.accessioned2016-12-20T09:30:50Z
dc.date.available2016-12-20T09:30:50Z
dc.date.issued2016-12-05
dc.date.updated2016-12-19T13:10:35Z
dc.description.abstractAsthma is a chronic respiratory disease whose prevalence is increasing in the western world. Recently research has begun to focus on the role the microbiome plays in asthma pathogenesis in the hope of further understanding this respiratory disorder. Considered sterile until recently, the lungs have revealed themselves to contain a unique microbiota. A shift towards molecular methods for the quantification and sequencing of microbial DNA has revealed that the airways harbour a unique microbiota with apparent, reproducible differences present between healthy and diseased lungs. There is a hope that in classifying the microbial load of the asthmatic airway an insight may be afforded as to the possible role pulmonary microbes may have in propagating an asthmatic airway response. This could potentially pave the way for new therapeutic strategies for the treatment of chronic lung conditions such as asthma.en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid163
dc.identifier.citationSullivan, A., Hunt, E., MacSharry, J., Murphy, D. M. (2016) 'The microbiome and the pathophysiology of asthma', Respiratory Research, 17:163 (11pp). doi:10.1186/s12931-016-0479-4en
dc.identifier.doi10.1186/s12931-016-0479-4
dc.identifier.endpage11en
dc.identifier.issn1465-993X
dc.identifier.journaltitleRespiratory Researchen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/3398
dc.identifier.volume17en
dc.language.isoenen
dc.publisherBioMed Centralen
dc.rights© 2016, the Authors. Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectAsthmaen
dc.subjectHosten
dc.subjectMicrobe dialogueen
dc.subjectTranslational researchen
dc.subjectMedicineen
dc.subjectInflammationen
dc.subjectMicrobiologyen
dc.subjectEpitheliumen
dc.subjectHygiene hypothesisen
dc.titleThe microbiome and the pathophysiology of asthmaen
dc.typeArticle (peer-reviewed)en
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