Timing of therapeutic hypothermia for inborn and outborn infants with neonatal encephalopathy

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dc.contributor.authorReaney, Laura
dc.contributor.authorLivingstone, Vicki
dc.contributor.authorBogue, Conor O.
dc.contributor.authorDempsey, Eugene M.
dc.contributor.authorFilan, Peter M.
dc.date.accessioned2017-11-13T16:42:28Z
dc.date.available2017-11-13T16:42:28Z
dc.date.issued2016-03
dc.date.updated2017-11-13T16:37:16Z
dc.description.abstractTherapeutic hypothermia is now the standard of care for infants with moderate to severe hypoxic ischaemic encephalopathy. Sixty-three infants received therapeutic hypothermia at Cork University Maternity Hospital (CUMH) from 2010-2014. Median gestational age was 40 weeks. Eighteen (29%) infants were Sarnat grade 3, 41(65%) grade 2 and 4(6%) grade 1. Nineteen outborn infants arrived in CUMH at a median (IQR) age of 310 (270, 420) minutes. Four (21%) outborn infants were within the target temperature range on arrival. Median (IQR) time (minutes) from birth to achieve target temperature was 136 (90, 195) for inborn and 300 (240, 360) for outborn infants (p <.01). Overall, 35 (56%) infants had electrical seizures, 42 (74%) had a normal MRI at a median (IQR) age of 7(6,9) days and the median(IQR) length of stay was 9 (7,11) days. Although no difference in seizures or MRI findings was seen, passive cooling does not achieve consistent temperature control for outborn infants.en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationReaney, L., Livingstone, V., Bogue, C. O., Dempsey, E. M., Filan, P. M. (2016) 'Timing of Therapeutic Hypothermia for Inborn and Outborn Infants with Neonatal Encephalopathy', Irish Medical Journal, 109 (3), 369. http://imj.ie/timing-of-therapeutic-hypothermia-for-inborn-and-outborn-infants-with-neonatal-encephalopathy/en
dc.identifier.issn0332-3102
dc.identifier.issued3en
dc.identifier.journaltitleIrish Medical Journalen
dc.identifier.startpage369en
dc.identifier.urihttps://hdl.handle.net/10468/5013
dc.identifier.volume109en
dc.language.isoenen
dc.publisherIrish Medical Organisationen
dc.relation.urihttp://imj.ie/timing-of-therapeutic-hypothermia-for-inborn-and-outborn-infants-with-neonatal-encephalopathy/
dc.rights© 2016, Irish Medical Organisation. All Rights Reserved.en
dc.subjectBrain diseaseen
dc.subjectControlled studyen
dc.subjectCoolingen
dc.subjectElectroencephalographyen
dc.subjectGestational ageen
dc.subjectInduced hypothermiaen
dc.subjectNewborn diseaseen
dc.subjectNewborn intensive careen
dc.subjectNewborn mortalityen
dc.subjectNuclear magnetic resonance imagingen
dc.subjectTemperature measurementen
dc.titleTiming of therapeutic hypothermia for inborn and outborn infants with neonatal encephalopathyen
dc.typeArticle (peer-reviewed)en
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