Non-invasive assessment of cartilage damage of the human knee using acoustic emission monitoring: A pilot cadaver study

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dc.contributor.authorKhokhlova, Liudmilaen
dc.contributor.authorKomaris, Dimitrios-Sokratisen
dc.contributor.authorDavarinos, Nikolaosen
dc.contributor.authorMahalingam, Karuppiahen
dc.contributor.authorO'Flynn, Brendanen
dc.contributor.authorTedesco, Salvatoreen
dc.contributor.funderScience Foundation Irelanden
dc.contributor.funderEuropean Regional Development Funden
dc.date.accessioned2023-10-31T15:31:54Z
dc.date.available2023-10-31T15:31:54Z
dc.date.issued2023-03-30en
dc.description.abstractObjective: Knee osteoarthritis is currently one of the top causes of disability in older population, a rate that will only increase in the future due to an aging population and the prevalence of obesity. However, objective assessment of treatment outcomes and remote evaluation are still in need of further development. Acoustic emission (AE) monitoring in knee diagnostics has been successfully adopted in the past; however, a wide discrepancy among the adopted AE techniques and analyses exists. This pilot study determined the most suitable metrics to differentiate progressive cartilage damage and the optimal frequency range and placement of AE sensors. Methods: Knee AEs were recorded in the 100–450 kHz and 15–200kH frequency ranges from a cadaver specimen in knee flexion/extension. Four stages of artificially inflicted cartilage damage and two sensor positions were investigated. Results: AE events in the lower frequency range and the following parameters provided better distinction between intact and damaged knee: hit amplitude, signal strength, and absolute energy. The medial condyle area of the knee was less prone to artefacts and unsystematic noise. Multiple reopenings of the knee compartment in the process of introducing the damage negatively affected the quality of the measurements. Conclusion: Results may improve AE recording techniques in future cadaveric and clinical studies. Significance: This was the first study to evaluate progressive cartilage damage using AEs in a cadaver specimen. The findings of this study encourage further investigation of joint AE monitoring techniques.en
dc.description.sponsorshipScience Foundation Ireland and European Regional Development Fund (Grant 12/RC/2289-P2 INSIGHT)en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationKhokhlova, L., Komaris, D. -S., Davarinos, N., Mahalingam, K., O'Flynn, B. and Tedesco, S. (2023) 'Non-invasive assessment of cartilage damage of the human knee using acoustic emission monitoring: A pilot cadaver study', IEEE Transactions on Biomedical Engineering, 70(9), pp. 2741-2751. doi: 10.1109/TBME.2023.3263388en
dc.identifier.doi10.1109/tbme.2023.3263388en
dc.identifier.eissn1558-2531en
dc.identifier.endpage2751en
dc.identifier.issn0018-9294en
dc.identifier.issued9en
dc.identifier.journaltitleIEEE Transactions on Biomedical Engineeringen
dc.identifier.startpage2741en
dc.identifier.urihttps://hdl.handle.net/10468/15169
dc.identifier.volume70en
dc.language.isoenen
dc.publisherInstitute of Electrical and Electronics Engineers (IEEE)en
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres/13/RC/2077/IE/CONNECT: The Centre for Future Networks & Communications/en
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres Programme::Phase 1/16/RC/3918/IE/Confirm Centre for Smart Manufacturing/en
dc.relation.project12/RC/2289-P2en
dc.rights© 2023, the Authors. This work is licensed under a Creative Commons Attribution 4.0 License.en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectAcoustic emissionen
dc.subjectJoint sounden
dc.subjectKnee healthen
dc.subjectOsteoarthritisen
dc.subjectThinning of the articular cartilageen
dc.subject~Tyndall National Institute - Journal Articles~en
dc.titleNon-invasive assessment of cartilage damage of the human knee using acoustic emission monitoring: A pilot cadaver studyen
dc.typeArticle (peer-reviewed)en
oaire.citation.issue9en
oaire.citation.volume70en
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