Model studies toward the synthesis of the bioactive diterpenoid, harringtonolide

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dc.contributor.authorO'Sullivan, Timothy P.
dc.contributor.authorZhang, Hongbin
dc.contributor.authorMander, Lewis N.
dc.date.accessioned2016-03-11T15:27:32Z
dc.date.available2016-03-11T15:27:32Z
dc.date.issued2007-06-19
dc.date.updated2015-09-07T12:30:52Z
dc.description.abstractIn model studies towards the synthesis of harringtonolide, the construction of the tropone moiety via arene cyclopropanation was investigated. The installation of the lactone ring was accomplished by way of a Diels-Alder cycloaddition of various indenones and 𝛼-pyones. The incorporation of the key bridge methyl group and subsequent control of its stereochemistry is also outlined.en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationO'SULLIVAN, T. P., ZHANG, H. & MANDER, L. N. 2007. Model studies toward the synthesis of the bioactive diterpenoid, harringtonolide. Organic & Biomolecular Chemistry, 5, 2627-2635. http://dx.doi.org/10.1039/B707467Ken
dc.identifier.doi10.1039/b707467k
dc.identifier.endpage2635en
dc.identifier.issn1477-0520
dc.identifier.issued16en
dc.identifier.journaltitleOrganic and Biomolecular Chemistryen
dc.identifier.startpage2627en
dc.identifier.urihttps://hdl.handle.net/10468/2429
dc.identifier.volume5en
dc.language.isoenen
dc.publisherRoyal Society of Chemistryen
dc.relation.isversionofhttp://pubs.rsc.org/en/content/articlepdf/2007/ob/b707467k
dc.rights© The Royal Society of Chemistry 2007en
dc.subjectCyclopropanationen
dc.subjectDiels-Alder cycloadditionen
dc.subjectDiterpenoiden
dc.subjectHarringtonolideen
dc.subjectLactone ringen
dc.subjectAromatic compoundsen
dc.subjectBioactivityen
dc.subjectBiosynthesisen
dc.subjectCyclopropanation reactionsen
dc.subjectKetonesen
dc.subjectLactonesen
dc.subjectFunctional groupsen
dc.subjectStereochemistryen
dc.subjectBiomoleculesen
dc.titleModel studies toward the synthesis of the bioactive diterpenoid, harringtonolideen
dc.typeArticle (peer-reviewed)en
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