Synthesis and evaluation of novel furanones as biofilm inhibitors in opportunistic human pathogens.

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dc.contributor.authorGómez, Andromeda-Celeste
dc.contributor.authorLyons, Thérèse
dc.contributor.authorMamat, Uwe
dc.contributor.authorYero, Daniel
dc.contributor.authorBravo, Marc
dc.contributor.authorDaura, Xavier
dc.contributor.authorElshafee, Osama
dc.contributor.authorBrunke, Sascha
dc.contributor.authorGahan, Cormac G. M.
dc.contributor.authorO'Driscoll, Michelle
dc.contributor.authorGibert, Isidre
dc.contributor.authorO'Sullivan, Timothy P.
dc.contributor.funderUniversity College Corken
dc.date.accessioned2022-09-15T14:58:22Z
dc.date.available2022-09-15T14:58:22Z
dc.date.issued2022-08-27
dc.date.updated2022-09-15T14:19:29Z
dc.description.abstractDiseases caused by biofilm-forming pathogens are becoming increasingly prevalent and represent a major threat to human health. This trend has prompted a search for novel inhibitors of microbial biofilms which could, for example, be used to potentiate existing antibiotics. Naturally-occurring, halogenated furanones isolated from marine algae have proven to be effective biofilm inhibitors in several bacterial species. In this work, we report the synthesis of a library of novel furanones and their subsequent evaluation as biofilm inhibitors in several opportunistic human pathogens including S. enterica, S. aureus, E. coli, S. maltophilia, P. aeruginosa and C. albicans. A number of the most potent compounds were subjected to further analysis by confocal laser-scanning microscopy for their effects on P. aeruginosa and C. albicans biofilms individually, in addition to mixed polymicrobial biofilms. Lastly, we investigated the impact of a promising candidate on survival rates in vivo using a Galleria mellonella model.en
dc.description.sponsorshipUniversity College Cork (School of Pharmacy University); Future University Egypt (PhD Scholarship); Science Foundation Ireland (APC Microbiome Ireland grant SFI/12/RC/2273_P2); Ministry for Science, Innovation and Universities (grant PID2019-111364RB-I00); Leibniz Association (financial support (grant SAS-2021-1-FZB of the Leibniz Research Alliance INFECTIONS in an Urbanizing World - Humans, Animals, Environments);en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid114678en
dc.identifier.citationGómez, A.-C., Lyons, T., Mamat, U., Yero, D., Bravo, M., Daura, X., Elshafee, O., Brunke, S., Gahan, C.G.M., O'Driscoll, M., Gibert, I. and O’Sullivan, T.P. (2022) ‘Synthesis and evaluation of novel furanones as biofilm inhibitors in opportunistic human pathogens’, European Journal of Medicinal Chemistry, 242, 114678 (16 pp). doi: 10.1016/j.ejmech.2022.114678en
dc.identifier.doi10.1016/j.ejmech.2022.114678en
dc.identifier.endpage16en
dc.identifier.issn1768-3254
dc.identifier.journaltitleEuropean Journal of Medicinal Chemistryen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/13611
dc.identifier.volume242en
dc.language.isoenen
dc.publisherElsevieren
dc.relation.urihttps://doi.org/10.1016/j.ejmech.2022.114678
dc.rights© 2022 The Authors. Published by Elsevier Masson SAS. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectFuranonesen
dc.subjectBiofilmsen
dc.subjectQuorum sensingen
dc.subjectSalmonella entericaen
dc.subjectStaphylococcus aureusen
dc.subjectPseudomonas aeruginosaen
dc.subjectEscherichia colien
dc.subjectStenotrophomonas maltophiliaen
dc.subjectCandida albicansen
dc.subject~Pharmacy - Journal Articles~en
dc.titleSynthesis and evaluation of novel furanones as biofilm inhibitors in opportunistic human pathogens.en
dc.typeArticle (peer-reviewed)en
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