Synthesis and evaluation of novel furanones as biofilm inhibitors in opportunistic human pathogens.

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dc.contributor.authorGómez, Andromeda-Celeste
dc.contributor.authorLyons, Thérèse
dc.contributor.authorMamat, Uwe
dc.contributor.authorYero, Daniel
dc.contributor.authorBravo, Marc
dc.contributor.authorDaura, Xavier
dc.contributor.authorElshafee, Osama
dc.contributor.authorBrunke, Sascha
dc.contributor.authorGahan, Cormac G. M.
dc.contributor.authorO'Driscoll, Michelle
dc.contributor.authorGibert, Isidre
dc.contributor.authorO'Sullivan, Timothy P.
dc.contributor.funderUniversity College Corken
dc.date.accessioned2022-09-15T14:58:22Z
dc.date.available2022-09-15T14:58:22Z
dc.date.issued2022-08-27
dc.date.updated2022-09-15T14:19:29Z
dc.description.abstractDiseases caused by biofilm-forming pathogens are becoming increasingly prevalent and represent a major threat to human health. This trend has prompted a search for novel inhibitors of microbial biofilms which could, for example, be used to potentiate existing antibiotics. Naturally-occurring, halogenated furanones isolated from marine algae have proven to be effective biofilm inhibitors in several bacterial species. In this work, we report the synthesis of a library of novel furanones and their subsequent evaluation as biofilm inhibitors in several opportunistic human pathogens including S. enterica, S. aureus, E. coli, S. maltophilia, P. aeruginosa and C. albicans. A number of the most potent compounds were subjected to further analysis by confocal laser-scanning microscopy for their effects on P. aeruginosa and C. albicans biofilms individually, in addition to mixed polymicrobial biofilms. Lastly, we investigated the impact of a promising candidate on survival rates in vivo using a Galleria mellonella model.en
dc.description.sponsorshipUniversity College Cork (School of Pharmacy University); Future University Egypt (PhD Scholarship); Science Foundation Ireland (APC Microbiome Ireland grant SFI/12/RC/2273_P2); Ministry for Science, Innovation and Universities (grant PID2019-111364RB-I00); Leibniz Association (financial support (grant SAS-2021-1-FZB of the Leibniz Research Alliance INFECTIONS in an Urbanizing World - Humans, Animals, Environments);en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid114678en
dc.identifier.citationGómez, A.-C., Lyons, T., Mamat, U., Yero, D., Bravo, M., Daura, X., Elshafee, O., Brunke, S., Gahan, C.G.M., O’Driscoll, M., Gibert, I. and O’Sullivan, T.P. (2022) ‘Synthesis and evaluation of novel furanones as biofilm inhibitors in opportunistic human pathogens’, European Journal of Medicinal Chemistry, 242, 114678 (16 pp). doi: 10.1016/j.ejmech.2022.114678en
dc.identifier.doi10.1016/j.ejmech.2022.114678en
dc.identifier.endpage16en
dc.identifier.issn1768-3254
dc.identifier.journaltitleEuropean Journal of Medicinal Chemistryen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/13611
dc.identifier.volume242en
dc.language.isoenen
dc.publisherElsevieren
dc.relation.urihttps://doi.org/10.1016/j.ejmech.2022.114678
dc.rights© 2022 The Authors. Published by Elsevier Masson SAS. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectFuranonesen
dc.subjectBiofilmsen
dc.subjectQuorum sensingen
dc.subjectSalmonella entericaen
dc.subjectStaphylococcus aureusen
dc.subjectPseudomonas aeruginosaen
dc.subjectEscherichia colien
dc.subjectStenotrophomonas maltophiliaen
dc.subjectCandida albicansen
dc.titleSynthesis and evaluation of novel furanones as biofilm inhibitors in opportunistic human pathogens.en
dc.typeArticle (peer-reviewed)en
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