Immunological outcomes of allergen-specific immunotherapy in food allergy

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dc.contributor.authorMalby Schoos, Ann-Marie
dc.contributor.authorBullens, Dominique
dc.contributor.authorLund Chawes, Bo
dc.contributor.authorCosta, Joana
dc.contributor.authorDe Vlieger, Liselot
dc.contributor.authorDunnGalvin, Audrey
dc.contributor.authorEpstein, Michelle M.
dc.contributor.authorGarssen, Johan
dc.contributor.authorHilger, Christiane
dc.contributor.authorKnipping, Karen
dc.contributor.authorKuehn, Annette
dc.contributor.authorMijakoski, Dragan
dc.contributor.authorMunblit, Daniel
dc.contributor.authorNekliudov, Nikita A.
dc.contributor.authorOzdemir, Cevdet
dc.contributor.authorPatient, Karine
dc.contributor.authorPeroni, Diego
dc.contributor.authorStoleski, Sasho
dc.contributor.authorStylianou, Eva
dc.contributor.authorTukalj, Mirjana
dc.contributor.authorVerhoeckx, Kitty
dc.contributor.authorZidarn, Mihaela
dc.contributor.authorvan de Veen, Willem
dc.contributor.funderEuropean Cooperation in Science and Technologyen
dc.contributor.funderFonds Wetenschappelijk Onderzoeken
dc.contributor.funderFundação para a Ciência e a Tecnologiaen
dc.contributor.funderFonds National de la Recherche Luxembourgen
dc.contributor.funderMinistry of Science and Higher Education of the Russian Federationen
dc.date.accessioned2022-09-20T11:51:02Z
dc.date.available2022-09-20T11:51:02Z
dc.date.issued2020-11-03
dc.date.updated2022-09-20T11:27:59Z
dc.description.abstractIgE-mediated food allergies are caused by adverse immunologic responses to food proteins. Allergic reactions may present locally in different tissues such as skin, gastrointestinal and respiratory tract and may result is systemic life-threatening reactions. During the last decades, the prevalence of food allergies has significantly increased throughout the world, and considerable efforts have been made to develop curative therapies. Food allergen immunotherapy is a promising therapeutic approach for food allergies that is based on the administration of increasing doses of culprit food extracts, or purified, and sometime modified food allergens. Different routes of administration for food allergen immunotherapy including oral, sublingual, epicutaneous and subcutaneous regimens are being evaluated. Although a wealth of data from clinical food allergen immunotherapy trials has been obtained, a lack of consistency in assessed clinical and immunological outcome measures presents a major hurdle for evaluating these new treatments. Coordinated efforts are needed to establish standardized outcome measures to be applied in food allergy immunotherapy studies, allowing for better harmonization of data and setting the standards for the future research. Several immunological parameters have been measured in food allergen immunotherapy, including allergen-specific immunoglobulin levels, basophil activation, cytokines, and other soluble biomarkers, T cell and B cell responses and skin prick tests. In this review we discuss different immunological parameters and assess their applicability as potential outcome measures for food allergen immunotherapy that may be included in such a standardized set of outcome measures.en
dc.description.sponsorshipEuropean Cooperation in Science and Technology (CA18227); Fonds Wetenschappelijk Onderzoek (TBM-project T001419N; Senior Clinical Investigatorship); Fundação para a Ciência e a Tecnologia (Partnership Agreement UIDB 50006/2020; AlleRiskAssess - PTDC/BAAAGR/31720/2017); Fonds National de la Recherche Luxembourg (PRIDE program grants PRIDE/11012546/NEXTIMMUNE; PRIDE17/11823097/MICROH); Ministry of Science and Higher Education of the Russian Federation (5-100 Russian Academic Excellence Project)en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid568598en
dc.identifier.citationMalby Schoos, A.-M., Bullens, D., Lund Chawes, B., Costa, J., De Vlieger, L., DunnGalvin, A., Epstein, M. M., Garssen, J., Hilger, C., Knipping, K., Kuehn, A., Mijakoski, D., Munblit, D., Nekliudov, N. A., Ozdemir, C., Patient, K., Peroni, D., Stoleski, S., Stylianou, E., Tukalj, M., Verhoeckx, K., Zidarn, M., van de Veen, W. on behalf of Core Outcome Measures for Food Allergy (COMFA) consortium (2020) ‘Immunological outcomes of allergen-specific immunotherapy in food allergy’, Frontiers in Immunology, 11, 568598 (20pp). doi: 10.3389/fimmu.2020.568598en
dc.identifier.doi10.3389/fimmu.2020.568598en
dc.identifier.eissn1664-3224
dc.identifier.endpage20en
dc.identifier.journaltitleFrontiers in Immunologyen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/13620
dc.identifier.volume11en
dc.language.isoenen
dc.publisherFrontiers Mediaen
dc.rights© 2020 Schoos, Bullens, Chawes, Costa, De Vlieger, DunnGalvin, Epstein, Garssen, Hilger, Knipping, Kuehn, Mijakoski, Munblit, Nekliudov, Ozdemir, Patient, Peroni, Stoleski, Stylianou, Tukalj, Verhoeckx, Zidarn and van de Veen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectFood allergyen
dc.subjectImmunotherapyen
dc.subjectToleranceen
dc.subjectOutcome measuresen
dc.subjectOral immunotherapyen
dc.subjectImmunologyen
dc.titleImmunological outcomes of allergen-specific immunotherapy in food allergyen
dc.typeArticle (peer-reviewed)en
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