An exploration of gut hormone therapy to treat infertility caused by Type 2 Diabetes
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Date
2024
Authors
Belle Martin, Alison
Duggan, Eileen
Journal Title
Journal ISSN
Volume Title
Publisher
UCC Medical Research and Technology Society
Published Version
Abstract
Background: Type II Diabetes Mellitus is a common disease associated with multiple debilitating symptoms, including reduced fertility in women of reproductive age. Gut hormone therapies have shown promise in improving fertility in these patients. Objectives: To identify the relationship between the human gut microbiota and the successful functioning of the female reproductive system. To explore treatments to improve bacteria culture in the gut, and to examine if these improvements affect fertility in female patients with Type II Diabetes. Method: A systematic search was undertaken; studies were collected from PubMed and The Diabetology and Metabolic Syndrome Journal. Searches were performed between January, 2023 and March, 2023. Studies focused on female patients suffering simultaneously from Type II Diabetes Mellitus and fertility complications. Ten papers that met criteria were appraised and included. Results: There is evidence to suggest a causative relationship between the gut microbiome and reproductive functioning. Infertile patients had increased abundance of the phylum Verrucomicrobia and Phascolarctobacterium in the gastrointestinal tract, and decreased amounts of genera Stenotrophomonas, Streptococcus, and Roseburia. These abnormalities were associated with depleted circulating oestrogen concentrations, irregular menstrual cycling, and hyperandrogenism. Evidence authenticates the use of probiotics and hormone therapy in treatment of Type II Diabetes and its associated symptoms. Supplements studied included metformin, GIP agonists, and GLP-1 receptors. Across studies, patients showed significant improvements in Type II Diabetes management following treatment. Conclusion: Alterations to the composition of the gut microbiome are associated with improvements in glycemic control as well as improvements in fertility in female patients with Type II Diabetes Mellitus.
Description
Keywords
Fertility , Type II diabetes , Family medicine , Endocrinology
Citation
Belle Martin, A. and Duggan, E. (2024) 'An exploration of gut hormone therapy to treat infertility caused by Type 2 Diabetes', UCC Student Medical Journal, 4, pp. 9-23. https://doi.org/10.33178/SMJ.2024.1.1