An exploration of gut hormone therapy to treat infertility caused by Type 2 Diabetes

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dc.contributor.authorBelle Martin, Alison
dc.contributor.authorDuggan, Eileen
dc.date.accessioned2024-09-12T10:32:40Z
dc.date.available2024-09-12T10:32:40Z
dc.date.issued2024
dc.description.abstractBackground: Type II Diabetes Mellitus is a common disease associated with multiple debilitating symptoms, including reduced fertility in women of reproductive age. Gut hormone therapies have shown promise in improving fertility in these patients. Objectives: To identify the relationship between the human gut microbiota and the successful functioning of the female reproductive system. To explore treatments to improve bacteria culture in the gut, and to examine if these improvements affect fertility in female patients with Type II Diabetes. Method: A systematic search was undertaken; studies were collected from PubMed and The Diabetology and Metabolic Syndrome Journal. Searches were performed between January, 2023 and March, 2023. Studies focused on female patients suffering simultaneously from Type II Diabetes Mellitus and fertility complications. Ten papers that met criteria were appraised and included. Results: There is evidence to suggest a causative relationship between the gut microbiome and reproductive functioning. Infertile patients had increased abundance of the phylum Verrucomicrobia and Phascolarctobacterium in the gastrointestinal tract, and decreased amounts of genera Stenotrophomonas, Streptococcus, and Roseburia. These abnormalities were associated with depleted circulating oestrogen concentrations, irregular menstrual cycling, and hyperandrogenism. Evidence authenticates the use of probiotics and hormone therapy in treatment of Type II Diabetes and its associated symptoms. Supplements studied included metformin, GIP agonists, and GLP-1 receptors. Across studies, patients showed significant improvements in Type II Diabetes management following treatment. Conclusion: Alterations to the composition of the gut microbiome are associated with improvements in glycemic control as well as improvements in fertility in female patients with Type II Diabetes Mellitus.en
dc.description.statusPeer-revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationBelle Martin, A. and Duggan, E. (2024) 'An exploration of gut hormone therapy to treat infertility caused by Type 2 Diabetes', UCC Student Medical Journal, 4, pp. 9-23. https://doi.org/10.33178/SMJ.2024.1.1en
dc.identifier.doihttps://doi.org/10.33178/SMJ.2024.1.1
dc.identifier.endpage23
dc.identifier.issn2737-7237
dc.identifier.journalabbrevUCC SMJ
dc.identifier.journaltitleUCC Student Medical Journalen
dc.identifier.startpage9
dc.identifier.urihttps://hdl.handle.net/10468/16355
dc.identifier.urihttps://journals.ucc.ie/index.php/smj/article/view/4119
dc.language.isoenen
dc.publisherUCC Medical Research and Technology Societyen
dc.rights© 2024, the Author(s). This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.en
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0
dc.sourceBatch uploaden
dc.subjectFertilityen
dc.subjectType II diabetesen
dc.subjectFamily medicineen
dc.subjectEndocrinologyen
dc.titleAn exploration of gut hormone therapy to treat infertility caused by Type 2 Diabetesen
dc.typeArticle (peer-reviewed)en
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