Investigation of halogenated furanones as inhibitors of quorum sensing-regulated bioluminescence in Vibrio harveyi
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Date
2023-03-17
Authors
Pinheiro, Jorge
Lyons, Thérèse
Las Heras, Vanessa
Recio, Miguel Villoria
Gahan, Cormac G. M.
O'Sullivan, Timothy P.
Journal Title
Journal ISSN
Volume Title
Publisher
Future Science Group
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Abstract
Aim: Vibrio harveyi is a Gram-negative marine bacterium that is a model system in the study of quorum sensing (QS). V. harveyi uses multichannel QS, mediated by three signaling molecules. The aim of this study was to synthesize and screen a diverse series of furanones for their potential to inhibit V. harveyi quorum sensing. Materials & methods: A library of halogenated furanones was prepared and derivatized using standard Pd-mediated coupling reactions and subsequently evaluated for their effects on V. harveyi bioluminescence. Results & conclusion: Several furanones inhibited QS-regulated bioluminescence, with gem-dichlorofuranone and tribromofuranone compounds proving especially effective. Importantly, a number of compounds were effective inhibitors of V. harveyi bioluminescence but did not have an impact on bacterial growth.
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Keywords
Bioluminescence , Furanones , Quorum sensing , Sonogashira , Suzuki , Vibrio harveyi
Citation
Pinheiro, J., Lyons, T., Las Heras, V., Recio, M. V., Gahan, C. G. M. and O'Sullivan, T. P. (2023) 'Investigation of halogenated furanones as inhibitors of quorum sensing-regulated bioluminescence in Vibrio harveyi', Future Medicinal Chemistry, 15(4), pp. 317-332. https://doi.org/10.4155/fmc-2022-0235
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© 2023, Newlands Press. Published with the permission of the publisher.