Investigation of halogenated furanones as inhibitors of quorum sensing-regulated bioluminescence in Vibrio harveyi

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dc.contributor.authorPinheiro, Jorge
dc.contributor.authorLyons, Thérèse
dc.contributor.authorLas Heras, Vanessa
dc.contributor.authorRecio, Miguel Villoria
dc.contributor.authorGahan, Cormac G. M.
dc.contributor.authorO'Sullivan, Timothy P.
dc.date.accessioned2024-05-20T09:25:33Z
dc.date.available2024-05-15T13:52:16Zen
dc.date.available2024-05-20T09:25:33Z
dc.date.issued2023-03-17
dc.date.updated2024-05-15T12:52:19Zen
dc.description.abstractAim: Vibrio harveyi is a Gram-negative marine bacterium that is a model system in the study of quorum sensing (QS). V. harveyi uses multichannel QS, mediated by three signaling molecules. The aim of this study was to synthesize and screen a diverse series of furanones for their potential to inhibit V. harveyi quorum sensing. Materials & methods: A library of halogenated furanones was prepared and derivatized using standard Pd-mediated coupling reactions and subsequently evaluated for their effects on V. harveyi bioluminescence. Results & conclusion: Several furanones inhibited QS-regulated bioluminescence, with gem-dichlorofuranone and tribromofuranone compounds proving especially effective. Importantly, a number of compounds were effective inhibitors of V. harveyi bioluminescence but did not have an impact on bacterial growth.en
dc.description.sponsorshipScience Foundation Ireland ( SFI/12/RC/2273_P2)
dc.description.statusPeer revieweden
dc.description.versionAccepted Version
dc.format.mimetypeapplication/pdfen
dc.identifier.citationPinheiro, J., Lyons, T., Las Heras, V., Recio, M. V., Gahan, C. G. M. and O'Sullivan, T. P. (2023) 'Investigation of halogenated furanones as inhibitors of quorum sensing-regulated bioluminescence in Vibrio harveyi', Future Medicinal Chemistry, 15(4), pp. 317-332. https://doi.org/10.4155/fmc-2022-0235
dc.identifier.doihttps://doi.org/10.4155/fmc-2022-0235
dc.identifier.eissn1756-8927
dc.identifier.endpage332
dc.identifier.issn1756-8919
dc.identifier.issued4
dc.identifier.journaltitleFuture Medicinal Chemistry
dc.identifier.startpage317
dc.identifier.urihttps://hdl.handle.net/10468/15879
dc.identifier.volume15
dc.language.isoenen
dc.publisherFuture Science Group
dc.rights© 2023, Newlands Press. Published with the permission of the publisher.
dc.subjectBioluminescence
dc.subjectFuranones
dc.subjectQuorum sensing
dc.subjectSonogashira
dc.subjectSuzuki
dc.subjectVibrio harveyi
dc.titleInvestigation of halogenated furanones as inhibitors of quorum sensing-regulated bioluminescence in Vibrio harveyi
dc.typeArticle (peer-reviewed)
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