Pen-on-Paper label-free surface-enhanced Raman scattering (SERS) detection of tetracycline in milk

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dc.contributor.authorRusso, Alidaen
dc.contributor.authorPiletti, Martinaen
dc.contributor.authorQuinn, Aidan J.en
dc.contributor.authorIacopino, Danielaen
dc.contributor.funderResearch Irelanden
dc.contributor.funderDepartment of Agriculture, Food and the Marine, Irelanden
dc.date.accessioned2026-01-30T17:07:35Z
dc.date.available2026-01-30T17:07:35Z
dc.date.issued2025-06-06en
dc.description.abstractMonitoring food quality requires the development of low-cost and sensitive analytical tools with label-free and point-of-site detection capabilities. Surface-enhanced Raman scattering (SERS) is a powerful analytical technique that combines fingerprint detection capabilities with high sensitivity. In this paper, we present the pen-on-paper fabrication of SERS substrates, whereby plasmonic nanoinks were written on a paper substrate and used for the detection of food contaminant residues. To construct sensitive and robust SERS sensors, four different nanoinks with different plasmonic properties were synthesized and tested on eight papers of different weights, textures, and hydrophilicities. The combination of silver nanoink and Bristol printing paper resulted in the strongest SERS substrate, which was used for crystal violet (CV) and tetracycline detection. Concentrations as low as 10–12 M were obtained for CV and 2.5 ppm of tetracycline in milk, showing the application potential of these paper-based SERS sensors for label-free detection of residuals in complex food matrices.en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationRusso, A., Piletti, M., Quinn, A.J. and Iacopino, D. (2025) 'Pen-on-paper label-free surface-enhanced raman scattering (Sers) detection of tetracycline in milk', ACS Omega, 10(23), pp. 24710–24719. https://doi.org/10.1021/acsomega.5c01637en
dc.identifier.doi10.1021/acsomega.5c01637en
dc.identifier.eissn2470-1343en
dc.identifier.endpage24719en
dc.identifier.issued23en
dc.identifier.journaltitleACS Omegaen
dc.identifier.startpage24710en
dc.identifier.urihttps://hdl.handle.net/10468/18495
dc.identifier.volume10en
dc.language.isoenen
dc.publisherAmerican Chemical Societyen
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/Research Centres Programme/16/RC/3835/IE/VistaMilk Centre/en
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/Research Centres Programme::Phase 2/13/RC/2077_P2/IE/CONNECT_Phase 2/en
dc.rights© 2025, the Authors. Published by the American Chemical Society.en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.statusPeer revieweden
dc.subjectBeveragesen
dc.subjectDairy productsen
dc.subjectMetal nanoparticlesen
dc.subjectRaman spectroscopyen
dc.subjectSensorsen
dc.titlePen-on-Paper label-free surface-enhanced Raman scattering (SERS) detection of tetracycline in milken
dc.typeArticle (peer-reviewed)en
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