Relationship between dietary quality, determined by DASH score, and cardiometabolic health biomarkers: a cross-sectional analysis in adults

Phillips, Catherine M.; Harrington, Janas M.; Perry, Ivan J.

Access to this article is restricted until 12 months after publication by request of the publisher.. Restriction lift date: 2019-09-01

Relationship between dietary quality, determined by DASH score, and cardiometabolic health biomarkers: a cross-sectional analysis in adults

Simple item page

dc.check.date	2019-09-01
dc.check.info	Access to this article is restricted until 12 months after publication by request of the publisher.	en
dc.contributor.author	Phillips, Catherine M.
dc.contributor.author	Harrington, Janas M.
dc.contributor.author	Perry, Ivan J.
dc.contributor.funder	Health Research Board	en
dc.date.accessioned	2018-11-05T12:15:09Z
dc.date.available	2018-11-05T12:15:09Z
dc.date.issued	2018-09-01
dc.date.updated	2018-10-24T08:21:24Z
dc.description.abstract	Background and aims: The relationship between dietary patterns and cardiometabolic disease is of increasing interest. However, limited data regarding the association between dietary quality and biomarkers of cardiometabolic health exist. Therefore the aim of this work was to examine potential associations between dietary quality, assessed using the Dietary Approaches to Stop Hypertension (DASH) dietary quality score, adiposity and biomarkers of glucose homeostasis, lipoprotein metabolism and inflammation in a cross-sectional sample of 1493 men and women. Methods: Anthropometric measurements included BMI, hip and waist circumference (WC). Serum acute-phase reactants, adipocytokines, pro-inflammatory cytokines and white blood cell (WBC) counts were determined. Lipoprotein particle size and subclass concentrations were measured using nuclear magnetic resonance (NMR) spectroscopy. Insulin resistance was calculated by homeostasis model assessment (HOMA-IR). Results: Higher dietary quality was associated with lower BMI (P < 0.05), WC (P < 0.001), tumour necrosis factor α (TNF-α), interleukin 6 (IL-6), WBC and plasminogen activator inhibitor-1 (PAI-1) concentrations (P < 0.01) and reduced insulin resistance (P < 0.05). In addition less small low density lipoprotein (LDL) and small high density lipoprotein (HDL) particles and less large very low density lipoprotein (VLDL) particles were observed among those with better dietary quality (P < 0.001). Individuals in the top DASH quartile had a 54% and 48% lower likelihood of central obesity and metabolic syndrome (MetS), respectively, than those in the lowest DASH quartile (P < 0.05). Conclusions: Our data suggest that higher quality diet is associated with improved adiposity measures and a less insulin resistant, pro-inflammatory, pro-thrombotic and pro-atherogenic cardiometabolic profile which may impact on central obesity and MetS risk. These findings, which may be of clinical and public health significance in terms of dietary approaches to promote cardiometabolic health, warrant further examination.	en
dc.description.sponsorship	Health Research Board (HRC/2007/13)	en
dc.description.status	Peer reviewed	en
dc.description.version	Accepted Version	en
dc.format.mimetype	application/pdf	en
dc.identifier.citation	Phillips, C. M., Harrington, J. M. and Perry, I. J. (2018) 'Relationship between dietary quality, determined by DASH score, and cardiometabolic health biomarkers: a cross-sectional analysis in adults', Clinical Nutrition. doi:10.1016/j.clnu.2018.08.028	en
dc.identifier.doi	10.1016/j.clnu.2018.08.028
dc.identifier.issn	0261-5614
dc.identifier.issn	1532-1983
dc.identifier.journaltitle	Clinical Nutrition	en
dc.identifier.uri	https://hdl.handle.net/10468/7060
dc.language.iso	en	en
dc.publisher	Elsevier Ltd.	en
dc.rights	© 2018, Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved. This manuscript version is made available under the CC-BY-NC-ND license.	en
dc.rights.uri	https://creativecommons.org/licenses/by-nc-nd/4.0/	en
dc.subject	Dietary quality	en
dc.subject	Inflammation	en
dc.subject	Lipoproteins	en
dc.subject	Insulin resistance	en
dc.subject	Obesity	en
dc.subject	Biomarkers	en
dc.title	Relationship between dietary quality, determined by DASH score, and cardiometabolic health biomarkers: a cross-sectional analysis in adults	en
dc.type	Article (peer-reviewed)	en