After a century of nisin research - where are we now?

Simple item page
dc.contributor.authorField, Desen
dc.contributor.authorFernández de Ullivarri, Miguelen
dc.contributor.authorRoss, R. Paulen
dc.contributor.authorHill, Colinen
dc.contributor.funderScience Foundation Irelanden
dc.date.accessioned2024-04-16T14:46:14Z
dc.date.available2024-04-16T14:46:14Z
dc.date.issued2023en
dc.description.abstractIt is almost a century since nisin was discovered in fermented milk cultures, coincidentally in the same year that penicillin was first described. Over the last 100 years this small, highly modified pentacyclic peptide has not only found success in the food industry as a preservative but has also served as the paradigm for our understanding of the genetic organization, expression, and regulation of genes involved in lantibiotic biosynthesis—one of the few cases of extensive post-translation modification in prokaryotes. Recent developments in understanding the complex biosynthesis of nisin have shed light on the cellular location of the modification and transport machinery and the co-ordinated series of spatio-temporal events required to produce active nisin and provide resistance and immunity. The continued unearthing of new natural variants from within human and animal gastrointestinal tracts has sparked interest in the potential application of nisin to influence the microbiome, given the growing recognition of the role the gastrointestinal microbiota plays in health and disease. Moreover, interdisciplinary approaches have taken advantage of biotechnological advance￾ments to bioengineer nisin to produce novel variants and expand nisin functionality for applications in the biomedical field. This review will discuss the latest progress in these aspects of nisin research.en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleidfuad023en
dc.identifier.citationField, D., Fernandez de Ullivarri, M., Ross, R.P. and Hill, C. (2023) ‘After a century of nisin research - where are we now?’, FEMS Microbiology Reviews, 47(3), fuad023, (18pp). doi:10.1093/femsre/fuad023en
dc.identifier.doi10.1093/femsre/fuad023en
dc.identifier.eissn1574-6976en
dc.identifier.endpage18en
dc.identifier.issn0168-6445en
dc.identifier.issued3en
dc.identifier.journaltitleFEMS Microbiology Reviewsen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/15804
dc.identifier.volume47en
dc.language.isoenen
dc.publisherOxford University Pressen
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/en
dc.rights© The Author(s) 2023. Published by Oxford University Press on behalf of FEMS. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectAntimicrobialen
dc.subjectLantibioticen
dc.subjectMicrobiomeen
dc.subjectNisinen
dc.subjectBioengineeringen
dc.subjectAntibiotic resistanceen
dc.titleAfter a century of nisin research - where are we now?en
dc.typeArticle (peer-reviewed)en
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
fuad023.pdf
Size:
1.93 MB
Format:
Adobe Portable Document Format
Description:
Published Version
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
2.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
APC Microbiome Ireland - Journal Articles
Microbiology - Journal Articles