The contribution of microbial biotechnology to sustainable development goals: microbiome therapies

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dc.contributor.authorO'Toole, Paul W.
dc.contributor.authorPaoli, Max
dc.contributor.funderSeventh Framework Programme
dc.contributor.funderDepartment of Agriculture, Food and the Marine
dc.contributor.funderScience Foundation Ireland
dc.date.accessioned2017-10-18T09:40:12Z
dc.date.available2017-10-18T09:40:12Z
dc.date.issued2017
dc.description.abstractComplex communities of microbes live on and in plants, humans and other animals. These communities are collectively referred to as the microbiota or microbiome. Plants and animals evolved to co-exist with these microbes. In mammals, particular kinds of alteration of the microbiome (dysbiosis) are associated with loss of health, most likely due to loss of microbial metabolites, signalling molecules, or regulators of host pathways. Modern life-style diseases such as Inflammatory Bowel Disease (IBD), Irritable Bowel Syndrome (IBS), type 2 diabetes, obesity and metabolic syndrome have been linked to dysbiosis. These multifactorial diseases involve multiple risk factors and triggers, depletion of certain gut microbiota species being one of them. Live Biotherapeutics operate by restoring microbial products or activities in affected subjects. They are being developed as adjuncts, alternatives or new treatment options for diseases that affect a growing proportion of global citizens.en
dc.description.sponsorshipScience Foundation Ireland (APC Microbiome Institute); Department of Agriculture, Food and the Marine (FIRM (ELDERFOOD and IMMUNOMET)en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationO'Toole, P. W. and Paoli, M. (2017) 'The contribution of microbial biotechnology to sustainable development goals: microbiome therapies', Microbial Biotechnology, 10(5), pp. 1066-1069. doi: 10.1111/1751-7915.12752en
dc.identifier.doi10.1111/1751-7915.12752
dc.identifier.endpage1069
dc.identifier.issn1751-7915
dc.identifier.issued5
dc.identifier.journaltitleMicrobial Biotechnologyen
dc.identifier.startpage1066
dc.identifier.urihttps://hdl.handle.net/10468/4881
dc.identifier.volume10
dc.language.isoenen
dc.publisherJohn Wiley & Sons, Inc.en
dc.relation.projectinfo:eu-repo/grantAgreement/EC/FP7::SP1::KBBE/613979/EU/Microbiome Influence on Energy balance and Brain Development-Function Put into Action to Tackle Diet-related Diseases and Behavior./MYNEWGUT
dc.relation.projectinfo:eu-repo/grantAgreement/EC/FP7::SP1::KBBE/266486/EU/New dietary strategies addressing the specific needs of elderly population for an healthy ageing in Europe/NU-AGE
dc.relation.urihttp://onlinelibrary.wiley.com/doi/10.1111/1751-7915.12752/abstract
dc.rights© 2017, the Authors. Microbial Biotechnology published by John Wiley & Sons Ltd and Society for Applied Microbiology. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectMicrobiotaen
dc.subjectDiseasesen
dc.subjectBiotechnologyen
dc.titleThe contribution of microbial biotechnology to sustainable development goals: microbiome therapiesen
dc.typeArticle (peer-reviewed)en
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